International Journal of Endocrinology / 2010 / Article / Tab 1

Research Article

Comparison of the Pharmacological Effects of Paricalcitol and Doxercalciferol on the Factors Involved in Mineral Homeostasis

Table 1

Physiological parameters in Sham rats or 5/6 nephrectomized rats fed a hyperphosphatemia-inducing diet.

ParametersSham5/6 NX-vehicle5/6 NX-paricalcitol5/6 NX-doxercalciferol
0.33  g/kg0.33  g/kg

Creatinine (mg/dL)0.45 ± 0.031.28 ± 0.13***1.57 ± 0.33**1.29 ± 0.11***
BUN (mg/dL)12.3 ± 0.359.1 ± 5.3***60.1 ± 9.0***60.5 ± 5.0***
Ionized Ca (mmil/L)1.35 ± 0.021.13 ± 0.04**1.26 ± 0.06#1.35 ± 0.03###
Total serum Ca (mg/dL)9.95 ± 0.138.99 ± 0.35**10.1 ± 0.27#10.93 ± 0.23**###
Total serum Pi (mg/dL)6.50 ± 0.2510.09 ± 0.76**12.05 ± 1.89*11.31 ± 1.05**
CaxPi ((mg/dL)2)64.8 ± 3.389.1 ± 4.0*120.3 ± 18.2*122.9 ± 10.6***###
Serum PTH142 ± 312504 ± 579**1031 ± 382*445 ± 135##

Mean ± SEM; , , versus Sham; , , versus NX-vehicle; = 8–11 per group.

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