Vitamin D Receptor Activation Mitigates the Impact of Uremia on Endothelial Function in the 5/6 Nephrectomized Rats
Figure 5
L-NAME abolished the effect of paricalcitol on improving endothelial dysfunction in 5/6 nephrectomized rats. SHAM and 5/6 NX rats were treated with vehicle or paricalcitol at 0.16 g/kg as described in “Materials and Methods” ( = 9–11 per group). Aortic rings were preincubated with 100 M L-NAME for 1 hour prior to the addition of PE to induce contraction, and the endothelium-dependent vasodilator acetylcholine was added in half-log increments (1 nM–30 M) at 3–5 minute intervals. (a) Acetylcholine-evoked relaxation. (b) Serum PTH. (c) Serum Ca.
