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International Journal of Endocrinology
Volume 2010 (2010), Article ID 681647, 3 pages
http://dx.doi.org/10.1155/2010/681647
Case Report

Black Thyroid Associated with Thyroid Carcinoma

1Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA
2Department of Pathology, Tulane University School of Medicine, New Orleans, LA 70112, USA
3Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
4Division of Endocrinology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA

Received 23 July 2010; Accepted 27 October 2010

Academic Editor: Dave Grattan

Copyright © 2010 Emad Kandil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Black thyroid is a rare pigmented change seen almost exclusively in patients upon minocycline ingestion, and the process has previously been thought to be generally benign. There have been 61 reported cases of black thyroid. We are aware of 13 cases previously reported in association with thyroid carcinoma. This paper reports six patients with black thyroid pigmentation in association with thyroid carcinoma. Design. The medical records of six patients who were diagnosed with black thyroid syndrome, all of whom underwent thyroid surgery, were reviewed. Data on age, gender, race, preoperative fine needle aspiration biopsy (FNA), thyroid function levels, and pathology reports were collected. Main Outcome. The mean age was 60 years. There were 5 females, 4 of whom were African American. All patients were clinically and biochemically euthyroid. Black pigmentation was not diagnosed in preoperative FNA, and only one patient had a preoperative diagnosis of papillary thyroid carcinoma. The other patients underwent surgery and were found to have black pigmentation of the thyroid associated with carcinoma. Conclusions. FNA does not diagnose black thyroid, which is associated with thyroid carcinoma. Thyroid glands with black pigmentation deserve thorough pathologic examination, including several sections of each specimen.