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International Journal of Endocrinology
Volume 2010, Article ID 759509, 9 pages
http://dx.doi.org/10.1155/2010/759509
Review Article

Sleep and Diabetes

1Section of Pulmonary, Critical and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Corpus Christi, TX 78413, USA
2Baylor College of Medicine, Texas A&M University, 613 Elizabeth Street, Suite 813, Corpus Christi, Houston, TX 78413, USA

Received 28 July 2009; Accepted 2 January 2010

Academic Editor: Jessica A. Mong

Copyright © 2010 Swetha Bopparaju and Salim Surani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Young, M. Palta, J. Dempsey, J. Skatrud, S. Weber, and S. Badr, “The occurrence of sleep-disordered breathing among middle-aged adults,” The New England Journal of Medicine, vol. 328, no. 17, pp. 1230–1235, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Young, P. E. Peppard, and D. J. Gottlieb, “Epidemiology of obstructive sleep apnea: a population health perspective,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 9, pp. 1217–1239, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Kapsimalis, G. Varouchakis, A. Manousaki et al., “Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea,” Lung, vol. 186, no. 4, pp. 209–217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. E. O. Bixler, A. N. Vgontzas, T. Ten Have, K. Tyson, and A. Kales, “Effects of age on sleep apnea in men. I. Prevalence and severity,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 1, pp. 144–148, 1998. View at Google Scholar · View at Scopus
  5. K. L. Knutson, K. Spiegel, P. Penev, and E. Van Cauter, “The metabolic consequences of sleep deprivation,” Sleep Medicine Reviews, vol. 11, no. 3, pp. 163–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. J. M. Marin, S. J. Carrizo, E. Vicente, and A. G. N. Agusti, “Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study,” The Lancet, vol. 365, no. 9464, pp. 1046–1053, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. M. I. Harris, K. M. Flegal, C. C. Cowie et al., “Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: the Third National Health and Nutrition Examination Survey, 1988–1994,” Diabetes Care, vol. 21, no. 4, pp. 518–524, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Young and P. Peppard, “Sleep-disordered breathing and cardiovascular disease: epidemiologic evidence for a relationship,” Sleep, vol. 23, supplement 4, pp. S122–S124, 2000. View at Google Scholar · View at Scopus
  9. P. E. Peppard, T. Young, M. Palta, and J. Skatrud, “Prospective study of the association between sleep-disordered breathing and hypertension,” The New England Journal of Medicine, vol. 342, no. 19, pp. 1378–1384, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. F. J. Nieto, T. B. Young, B. K. Lind et al., “Association of sleep-disordered breathing sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study,” Journal of the American Medical Association, vol. 283, no. 14, pp. 1829–1836, 2000. View at Google Scholar · View at Scopus
  11. E. Shahar, C. W. Whitney, S. Redline et al., “Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 1, pp. 19–25, 2001. View at Google Scholar · View at Scopus
  12. J. L. Kiely and W. T. McNicholas, “Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome,” European Respiratory Journal, vol. 16, no. 1, pp. 128–133, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. P. D. Levinson, S. T. McGarvey, C. C. Carlisle, S. E. Eveloff, P. N. Herbert, and R. P. Millman, “Adiposity and cardiovascular risk factors in men with obstructive sleep apnea,” Chest, vol. 103, no. 5, pp. 1336–1342, 1993. View at Google Scholar · View at Scopus
  14. E. Tasali and M. S. M. Ip, “Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation,” Proceedings of the American Thoracic Society, vol. 5, no. 2, pp. 207–217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. R. Coughlin, L. Mawdsley, J. A. Mugarza, P. M. A. Calverley, and J. P. H. Wilding, “Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome,” European Heart Journal, vol. 25, no. 9, pp. 735–741, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Lévy, M. R. Bonsignore, and J. Eckel, “Sleep, sleep-disordered breathing and metabolic consequences,” European Respiratory Journal, vol. 34, no. 1, pp. 243–260, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Tasali, B. Mokhlesi, and E. Van Cauter, “Obstructive sleep apnea and type 2 diabetes: interacting epidemics,” Chest, vol. 133, no. 2, pp. 496–506, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. C. Peltier, F. B. Consens, K. Sheikh, L. Wang, Y. Song, and J. W. Russell, “Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulation,” Sleep Medicine, vol. 8, no. 2, pp. 149–155, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. N. Vgontzas, R. S. Legro, E. O. Bixler, A. Grayev, A. Kales, and G. P. Chrousos, “Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 2, pp. 517–520, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. H. E. Resnick, S. Redline, E. Shahar et al., “Diabetes and sleep disturbances: findings from the Sleep Heart Health Study,” Diabetes Care, vol. 26, no. 3, pp. 702–709, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. E. O. Bixler, A. N. Vgontzas, H.-M. Lin et al., “Prevalence of sleep-disordered breathing in women: effects of gender,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 3, part 1, pp. 608–613, 2001. View at Google Scholar · View at Scopus
  22. S. Redline, K. Kump, P. V. Tishler, I. Browner, and V. Ferrette, “Gender differences in sleep disordered breathing in a community-based sample,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 3, part 1, pp. 722–726, 1994. View at Google Scholar · View at Scopus
  23. A. B. Newman, F. J. Nieto, U. Guidry et al., “Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study,” American Journal of Epidemiology, vol. 154, no. 1, pp. 50–59, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Young, E. Shahar, F. J. Nieto et al., “Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study,” Archives of Internal Medicine, vol. 162, no. 8, pp. 893–900, 2002. View at Google Scholar · View at Scopus
  25. J. Durán, S. Esnaola, R. Rubio, and A. Iztueta, “Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 3, part 1, pp. 685–689, 2001. View at Google Scholar · View at Scopus
  26. S. Redline, P. V. Tishler, M. G. Hans, T. D. Tosteson, K. P. Strohl, and K. Spry, “Racial differences in sleep-disordered breathing in African-Americans and Caucasians,” American Journal of Respiratory and Critical Care Medicine, vol. 155, no. 1, pp. 186–192, 1997. View at Google Scholar · View at Scopus
  27. V. K. Somers, M. E. Dyken, M. P. Clary, and F. M. Abboud, “Sympathetic neural mechanisms in obstructive sleep apnea,” Journal of Clinical Investigation, vol. 96, no. 4, pp. 1897–1904, 1995. View at Google Scholar · View at Scopus
  28. G. V. Robinson, J. R. Stradling, and R. J. O. Davies, “Obstructive sleep apnoea/hypopnoea syndrome and hypertension,” Thorax, vol. 59, no. 12, pp. 1089–1094, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. G. S. Hamilton, P. Solin, and M. T. Naughton, “Obstructive sleep apnoea and cardiovascular disease,” Internal Medicine Journal, vol. 34, no. 7, pp. 420–426, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. N. M. Punjabi, M. M. Ahmed, V. Y. Polotsky, B. A. Beamer, and C. P. O'Donnell, “Sleep-disordered breathing, glucose intolerance, and insulin resistance,” Respiratory Physiology and Neurobiology, vol. 136, no. 2-3, pp. 167–178, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. N. M. Punjabi, J. D. Sorkin, L. I. Katzel, A. P. Goldberg, A. R. Schwartz, and P. L. Smith, “Sleep-disordered breathing and insulin resistance in middle-aged and overweight men,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 5, pp. 677–682, 2002. View at Google Scholar · View at Scopus
  32. K. J. Reichmuth, D. Austin, J. B. Skatrud, and T. Young, “Association of sleep apnea and type II diabetes: a population-based study,” American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 12, pp. 1590–1595, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. A. H. Mokdad, B. A. Bowman, E. S. Ford, F. Vinicor, J. S. Marks, and J. P. Koplan, “The continuing epidemics of obesity and diabetes in the United States,” Journal of the American Medical Association, vol. 286, no. 10, pp. 1195–1200, 2001. View at Google Scholar · View at Scopus
  34. R. J. O. Davies, N. J. Ali, and J. R. Stradling, “Neck circumference and other clinical features in the diagnosis of the obstructive sleep apnoea syndrome,” Thorax, vol. 47, no. 2, pp. 101–105, 1992. View at Google Scholar · View at Scopus
  35. R. J. O. Davies and J. R. Stradling, “The relationship between neck circumference, radiographic pharyngeal anatomy, and the obstructive sleep apneoa syndrome,” European Respiratory Journal, vol. 3, no. 5, pp. 509–514, 1990. View at Google Scholar · View at Scopus
  36. R. Grunstein, I. Wilcox, T.-S. Yang, Y. Gould, and J. Hedner, “Snoring and sleep apnoea in men: association with central obesity and hypertenslon,” International Journal of Obesity, vol. 17, no. 9, pp. 533–540, 1993. View at Google Scholar · View at Scopus
  37. V. Hoffstein and S. Mateika, “Differences in abdominal and neck circumferences in patients with and without obstructive sleep apnoea,” European Respiratory Journal, vol. 5, no. 4, pp. 377–381, 1992. View at Google Scholar · View at Scopus
  38. I. Katz, J. Stradling, A. S. Slutsky, N. Zamel, and V. Hoffstein, “Do patients with obstructive sleep apnea have thick necks?” American Review of Respiratory Disease, vol. 141, no. 5, part 1, pp. 1228–1231, 1990. View at Google Scholar · View at Scopus
  39. P. D. Levinson, S. T. McGarvey, C. C. Carlisle, S. E. Eveloff, P. N. Herbert, and R. P. Millman, “Adiposity and cardiovascular risk factors in men with obstructive sleep apnea,” Chest, vol. 103, no. 5, pp. 1336–1342, 1993. View at Google Scholar · View at Scopus
  40. R. P. Millman, C. C. Carlisle, S. T. McGarvey, S. E. Eveloff, and P. D. Levinson, “Body fat distribution and sleep apnea severity in women,” Chest, vol. 107, no. 2, pp. 362–366, 1995. View at Google Scholar · View at Scopus
  41. E. Shinohara, S. Kihara, S. Yamashita et al., “Visceral fat accumulation as an important risk factor for obstructive sleep apnoea syndrome in obese subjects,” Journal of Internal Medicine, vol. 241, no. 1, pp. 11–18, 1997. View at Google Scholar · View at Scopus
  42. A. H. Mokdad, B. A. Bowman, E. S. Ford, F. Vinicor, J. S. Marks, and J. P. Koplan, “The continuing epidemics of obesity and diabetes in the United States,” Journal of the American Medical Association, vol. 286, no. 10, pp. 1195–1200, 2001. View at Google Scholar · View at Scopus
  43. C. Guilleminault, A. Bassiri, and M. A. Caskadon, “Clinical features and evaluation of obstructive sleep apnea-hypopnea syndrome and upper airway resistance syndrome,” in Principles and Practice of Sleep Medicine, M. H. Kryger, T. Roth, and W. C. Dement, Eds., pp. 1043–1052, Elsevier Saunders, Philadelphia, Pa, USA, 2nd edition, 2005. View at Google Scholar
  44. D. L. Bliwise, D. E. Feldman, N. G. Bliwise et al., “Risk factor for sleep disordered breathing in heterogeneous geriatric populations,” Journal of the American Geriatrics Society, vol. 35, no. 2, pp. 132–141, 1987. View at Google Scholar · View at Scopus
  45. N. M. Punjabi and V. Y. Polotsky, “Disorders of glucose metabolism in sleep apnea,” Journal of Applied Physiology, vol. 99, no. 5, pp. 1998–2007, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. I. A. Harsch, S. P. Schahin, M. Radespiel-Tröger et al., “Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 169, no. 2, pp. 156–162, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. N. M. Punjabi, E. Shahar, S. Redline, D. J. Gottlieb, R. Givelber, and H. E. Resnick, “Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study,” American Journal of Epidemiology, vol. 160, no. 6, pp. 521–530, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Elmasry, E. Lindberg, C. Berne et al., “Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study,” Journal of Internal Medicine, vol. 249, no. 2, pp. 153–161, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. M. S. M. Ip, B. Lam, M. M. T. Ng, W. K. Lam, K. W. T. Tsang, and K. S. L. Lam, “Obstructive sleep apnea is independently associated with insulin resistance,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 5, pp. 670–676, 2002. View at Google Scholar · View at Scopus
  50. N. Meslier, F. Gagnadoux, P. Giraud et al., “Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome,” European Respiratory Journal, vol. 22, no. 1, pp. 156–160, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. V. Y. Polotsky, J. Li, N. M. Punjabi et al., “Intermittent hypoxia increases insulin resistance in genetically obese mice,” Journal of Physiology, vol. 552, no. 1, pp. 253–264, 2003. View at Publisher · View at Google Scholar · View at Scopus
  52. A. N. Vgontzas, D. A. Papanicolaou, E. O. Bixler, A. Kales, K. Tyson, and G. P. Chrousos, “Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 5, pp. 1313–1316, 1997. View at Google Scholar · View at Scopus
  53. E. Spath-Schwalbe, M. Gofferje, W. Kern, J. Born, and H. L. Fehm, “Sleep disruption alters nocturnal ACTH and cortisol secretory patterns,” Biological Psychiatry, vol. 29, no. 6, pp. 575–584, 1991. View at Publisher · View at Google Scholar · View at Scopus
  54. K. Spiegel, R. Leproult, and E. Van Cauter, “Impact of sleep debt on metabolic and endocrine function,” The Lancet, vol. 354, no. 9188, pp. 1435–1439, 1999. View at Publisher · View at Google Scholar · View at Scopus
  55. K. M. Flegal, M. D. Carroll, C. L. Ogden, and C. L. Johnson, “Prevalence and trends in obesity among US adults, 1999-2000,” Journal of the American Medical Association, vol. 288, no. 14, pp. 1723–1727, 2002. View at Google Scholar · View at Scopus
  56. K. M. Flegal and R. P. Troiano, “Changes in the distribution of body mass index of adults and children in the US population,” International Journal of Obesity, vol. 24, no. 7, pp. 807–818, 2000. View at Google Scholar · View at Scopus
  57. A. A. Hedley, C. L. Ogden, C. L. Johnson, M. D. Carroll, L. R. Curtin, and K. M. Flegal, “Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002,” Journal of the American Medical Association, vol. 291, no. 23, pp. 2847–2850, 2004. View at Publisher · View at Google Scholar · View at Scopus
  58. G. Reaven, “Role of insulin resistance in human disease. Banting lecture,” Diabetes, vol. 37, no. 12, pp. 1595–1607, 1997. View at Google Scholar · View at Scopus
  59. I. A. Harsch, S. P. Schahin, K. Brückner et al., “The effect of continuous positive airway pressure treatment on insulin sensitivity in patients with obstructive sleep apnoea syndrome and type 2 diabetes,” Respiration, vol. 71, no. 3, pp. 252–259, 2004. View at Publisher · View at Google Scholar · View at Scopus
  60. H. Schäfer, D. Pauleit, T. Sudhop, I. Gouni-Berthold, S. Ewig, and H. K. Berthold, “Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea,” Chest, vol. 122, no. 3, pp. 829–839, 2002. View at Publisher · View at Google Scholar · View at Scopus
  61. O. Kokturk, T. U. Ciftci, E. Mollarecep, and B. Ciftci, “Elevated C-reactive protein levels and increased cardiovascular risk in patients with obstructive sleep apnea syndrome,” International Heart Journal, vol. 46, no. 5, pp. 801–809, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. N. M. Punjabi and B. A. Beamer, “C-reactive protein is associated with sleep disordered breathing independent of adiposity,” Sleep, vol. 30, no. 1, pp. 29–34, 2007. View at Google Scholar · View at Scopus
  63. A. S. Gami, S. M. Caples, and V. K. Somers, “Obesity and obstructive sleep apnea,” Endocrinology and Metabolism Clinics of North America, vol. 32, no. 4, pp. 869–894, 2003. View at Publisher · View at Google Scholar · View at Scopus
  64. G. M. Reaven, “Role of insulin resistance in human disease,” Diabetes, vol. 37, no. 12, pp. 1595–1607, 1988. View at Google Scholar
  65. M. Visser, L. M. Bouter, G. M. McQuillan, M. H. Wener, and T. B. Harris, “Elevated C-reactive protein levels in overweight and obese adults,” Journal of the American Medical Association, vol. 282, no. 22, pp. 2131–2135, 1999. View at Publisher · View at Google Scholar · View at Scopus
  66. R. V. Considine, M. K. Sinha, M. L. Heiman et al., “Serum immunoreactive-leptin concentrations in normal-weight and obese humans,” The New England Journal of Medicine, vol. 334, no. 5, pp. 292–295, 1996. View at Publisher · View at Google Scholar · View at Scopus
  67. K. P. Strohl, R. D. Novak, W. Singer et al., “Insulin levels, blood pressure and sleep apnea,” Sleep, vol. 17, no. 7, pp. 614–618, 1994. View at Google Scholar · View at Scopus
  68. D. P. White, “Pathophysiology of obstructive sleep apnoea,” Thorax, vol. 50, no. 7, pp. 797–804, 1995. View at Google Scholar · View at Scopus
  69. R. A. Stoohs, F. Facchini, and C. Guilleminault, “Insulin resistance and sleep-disordered breathing in healthy humans,” American Journal of Respiratory and Critical Care Medicine, vol. 154, no. 1, pp. 170–174, 1996. View at Google Scholar · View at Scopus
  70. F. Rosenow, V. McCarthy, and A. C. Caruso, “Sleep apnoea in endocrine diseases,” Journal of Sleep Research, vol. 7, no. 1, pp. 3–11, 1998. View at Publisher · View at Google Scholar · View at Scopus
  71. E. Van Cauter, U. Holmbäck, K. Knutson et al., “Impact of sleep and sleep loss on neuroendocrine and metabolic function,” Hormone Research, vol. 67, supplement 1, pp. 2–9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  72. K. Spiegel, R. Leproult, and E. Van Cauter, “Impact of sleep debt on metabolic and endocrine function,” The Lancet, vol. 354, no. 9188, pp. 1435–1439, 1999. View at Publisher · View at Google Scholar · View at Scopus
  73. M. Tiihonen, M. Partinen, and S. Narvanen, “The severity of obstructive sleep apnoea is associated with insulin resistance,” Journal of Sleep Research, vol. 2, no. 1, pp. 56–61, 1993. View at Google Scholar · View at Scopus
  74. R. J. O. Davies, R. Turner, J. Crosby, and J. R. Stradling, “Plasma insulin and lipid levels in untreated obstructive sleep apnoea and snoring; their comparison with matched controls and response to treatment,” Journal of Sleep Research, vol. 3, no. 3, pp. 180–185, 1994. View at Google Scholar · View at Scopus
  75. D. Manzella, M. Parillo, T. Razzino et al., “Soluble leptin receptor and insulin resistance as determinant of sleep apnea,” International Journal of Obesity, vol. 26, no. 3, pp. 370–375, 2002. View at Publisher · View at Google Scholar · View at Scopus
  76. J. H. Ficker, S. H. Dertinger, W. Siegfried et al., “Obstructive sleep apnoea and diabetes mellitus: the role of cardiovascular autonomic neuropathy,” European Respiratory Journal, vol. 11, no. 1, pp. 14–19, 1998. View at Publisher · View at Google Scholar · View at Scopus
  77. C. Neumann, D. Martinez, and H. Schmid, “Nocturnal oxygen desaturation in diabetic patients with severe autonomic neuropathy,” Diabetes Research and Clinical Practice, vol. 28, no. 2, pp. 97–102, 1995. View at Publisher · View at Google Scholar · View at Scopus
  78. S. Joo, S. Lee, H. A. Choi et al., “Habitual snoring is associated with elevated hemoglobin A1c levels in non-obese middle-aged adults,” Journal of Sleep Research, vol. 15, no. 4, pp. 437–444, 2006. View at Publisher · View at Google Scholar · View at Scopus
  79. N. Meslier, F. Gagnadoux, P. Giraud et al., “Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome,” European Respiratory Journal, vol. 22, no. 1, pp. 156–160, 2003. View at Publisher · View at Google Scholar · View at Scopus
  80. J. J. Larsen, J. M. Hansen, N. V. Olsen, H. Galbo, and F. Dela, “The effect of altitude hypoxia on glucose homeostasis in men,” Journal of Physiology, vol. 504, no. 1, pp. 241–249, 1997. View at Publisher · View at Google Scholar · View at Scopus
  81. F. Barbé, L. R. Mayoralas, J. Duran et al., “Treatment with continuous positive airway pressure is not effective in patients with sleep apnea but no daytime sleepiness: a randomized, controlled trial,” Annals of Internal Medicine, vol. 134, no. 11, pp. 1015–1023, 2001. View at Google Scholar · View at Scopus
  82. E. Lindberg, C. Berne, K. A. Franklin, M. Svensson, and C. Janson, “Snoring and daytime sleepiness as risk factors for hypertension and diabetes in women—a population-based study,” Respiratory Medicine, vol. 101, no. 6, pp. 1283–1290, 2007. View at Publisher · View at Google Scholar · View at Scopus
  83. G. V. Robinson, D. M. Smith, B. A. Langford, R. J. O. Davies, and J. R. Stradling, “Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients,” European Respiratory Journal, vol. 27, no. 6, pp. 1229–1235, 2006. View at Publisher · View at Google Scholar · View at Scopus
  84. N. M. Punjabi, J. D. Sorkin, L. I. Katzel, A. P. Goldberg, A. R. Schwartz, and P. L. Smith, “Sleep-disordered breathing and insulin resistance in middle-aged and overweight men,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 5, pp. 677–682, 2002. View at Google Scholar · View at Scopus
  85. J. H. Ficker, S. H. Dertinger, W. Siegfried et al., “Obstructive sleep apnoea and diabetes mellitus: the role of cardiovascular autonomic neuropathy,” European Respiratory Journal, vol. 11, no. 1, pp. 14–19, 1998. View at Publisher · View at Google Scholar · View at Scopus
  86. K. Narkiewicz, P. J. H. van de Borne, R. L. Cooley, M. E. Dyken, and V. K. Somers, “Sympathetic activity in obese subjects with and without obstructive sleep apnea,” Circulation, vol. 98, no. 8, pp. 772–776, 1998. View at Google Scholar · View at Scopus
  87. T. Watanabe, T. Mano, S. Iwase et al., “Enhanced muscle sympathetic nerve activity during sleep apnea in the elderly,” Journal of the Autonomic Nervous System, vol. 37, no. 3, pp. 223–226, 1992. View at Publisher · View at Google Scholar · View at Scopus
  88. T. V. Coy, J. E. Dimsdale, S. Ancoli-Israel, and J. Clausen, “Sleep apnoea and sympathetic nervous system activity: a review,” Journal of Sleep Research, vol. 5, no. 1, pp. 42–50, 1996. View at Google Scholar · View at Scopus
  89. J. Saini, J. Krieger, G. Brandenberger, G. Wittersheim, C. Simon, and M. Follenius, “Continuous positive airway pressure treatment. Effects on growth hormone, insulin and glucose profiles in obstructive sleep apnea patients,” Hormone and Metabolic Research, vol. 25, no. 7, pp. 375–381, 1993. View at Google Scholar · View at Scopus
  90. R. L. Williams, “Sleep disturbances in various medical and surgical conditions,” in Sleep Disorders: Diagnosis and Treatment, R. L. Williams, I. Karacan, and C. A. Moore, Eds., pp. 265–292, Wiley, New York, NY, USA, 1988. View at Google Scholar
  91. R. Leproult, G. Copinschi, O. Buxton, and E. Van Cauter, “Sleep loss results in an elevation of cortisol levels the next evening,” Sleep, vol. 20, no. 10, pp. 865–870, 1997. View at Google Scholar · View at Scopus
  92. G. S. Hotamisligil, N. S. Shargill, and B.M. Spiegelman, “Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance,” Science, vol. 259, no. 5091, pp. 87–91, 1993. View at Google Scholar · View at Scopus
  93. K. Rebrin, G. M. Steil, S. D. Mittelman, and R. N. Bergman, “Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs,” Journal of Clinical Investigation, vol. 98, no. 3, pp. 741–749, 1996. View at Google Scholar · View at Scopus
  94. R. Hertz, J. Magenheim, I. Berman, and J. Bar-Tana, “Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α,” Nature, vol. 392, no. 6675, pp. 512–516, 1998. View at Publisher · View at Google Scholar · View at Scopus
  95. Y. T. Kruszynska, D. S. Worrall, J. Ofrecio, J. P. Frias, G. Macaraeg, and J. M. Olefsky, “Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 1, pp. 226–234, 2002. View at Publisher · View at Google Scholar · View at Scopus
  96. J. Nieto, S. Surani, A. L. Huerta-Alardín, and J. Varon, “Sleep-related disorders, diabetes and obesity: understanding the facts,” Current Respiratory Medicine Reviews, vol. 2, no. 3, pp. 325–329, 2006. View at Publisher · View at Google Scholar · View at Scopus
  97. B. E. Wisse, “The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity,” Journal of the American Society of Nephrology, vol. 15, no. 11, pp. 2792–2800, 2004. View at Publisher · View at Google Scholar · View at Scopus
  98. N. Barzilai, J. Wang, D. Massilon, P. Vuguin, M. Hawkins, and L. Rossetti, “Leptin selectively decreases visceral adiposity and enhances insulin action,” Journal of Clinical Investigation, vol. 100, no. 12, pp. 3105–3110, 1997. View at Google Scholar · View at Scopus
  99. V. K. Somers, M. E. Dyken, M. P. Clary, and F. M. Abboud, “Sympathetic neural mechanisms in obstructive sleep apnea,” Journal of Clinical Investigation, vol. 96, no. 4, pp. 1897–1904, 1995. View at Google Scholar · View at Scopus
  100. V. K. Somers, A. L. Mark, D. C. Zavala, and F. M. Abboud, “Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans,” Journal of Applied Physiology, vol. 67, no. 5, pp. 2101–2106, 1989. View at Google Scholar · View at Scopus
  101. T. M. S. Wolever, “Carbohydrate and the regulation of blood glucose and metabolism,” Nutrition Reviews, vol. 61, no. 5, part 2, pp. S40–S48, 2003. View at Google Scholar · View at Scopus
  102. W. Kern, S. Offenheuser, J. Born, and H. L. Fehm, “Entrainment of ultradian oscillations in the secretion of insulin and glucagon to the nonrapid eye movement/rapid eye movement sleep rhythm in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 4, pp. 1541–1547, 1996. View at Publisher · View at Google Scholar · View at Scopus
  103. E. Van Cauter, J. D. Blackman, D. Roland, J.-P. Spire, S. Refetoff, and K. S. Polonsky, “Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep,” Journal of Clinical Investigation, vol. 88, no. 3, pp. 934–942, 1991. View at Google Scholar · View at Scopus
  104. E. Van Cauter, K. S. Polonsky, and A. J. Scheen, “Roles of circadian rhythmicity and sleep in human glucose regulation,” Endocrine Reviews, vol. 18, no. 5, pp. 716–738, 1997. View at Publisher · View at Google Scholar · View at Scopus
  105. P. Maquet, “Functional neuroimaging of normal human sleep by positron emission tomography,” Journal of Sleep Research, vol. 9, no. 3, pp. 207–231, 2000. View at Publisher · View at Google Scholar · View at Scopus
  106. R. M. Abrams, A. A. Hutchison, T. M. Jay, L. Sokoloff, and C. Kennedy, “Local cerebral glucose utilization non-selectively elevated in rapid eye movement sleep of the fetus,” Brain Research, vol. 468, no. 1, pp. 65–70, 1988. View at Google Scholar · View at Scopus
  107. A. R. Braun, T. J. Balkin, N. J. Wesensten et al., “Regional cerebral blood flow throughout the sleep-wake cycle. An H215O PET study,” Brain, vol. 120, no. 7, pp. 1173–1197, 1997. View at Publisher · View at Google Scholar · View at Scopus
  108. W. Kern, S. Offenheuser, J. Born, and H. L. Fehm, “Entrainment of ultradian oscillations in the secretion of insulin and glucagon to the nonrapid eye movement/rapid eye movement sleep rhythm in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 4, pp. 1541–1547, 1996. View at Publisher · View at Google Scholar · View at Scopus
  109. B. Yee, P. Liu, C. Philips, and R. Grunstein, “Neuroendocrine changes in sleep apnea,” Current Opinion in Pulmonary Medicine, vol. 10, no. 6, pp. 475–481, 2004. View at Google Scholar · View at Scopus
  110. H. Weiss and P. Spiegler, “The impact of continuous positive airway pressure on insulin resistance in patients with obstructive sleep apnea,” Clinical Pulmonary Medicine, vol. 11, no. 3, pp. 196–197, 2004. View at Publisher · View at Google Scholar · View at Scopus
  111. V. K. Somers, M. E. Dyken, A. L. Mark, and F. M. Abboud, “Sympathetic-nerve activity during sleep in normal subjects,” The New England Journal of Medicine, vol. 328, no. 5, pp. 303–307, 1993. View at Publisher · View at Google Scholar · View at Scopus
  112. S. Surani, R. Aguillar, V. Komari, A. Surani, and S. Subramanian, “Influence of Hispanic ethnicity in prevalence of diabetes mellitus on sleep apnea and relationship to sleep phase,” Postgraduate Medicine, vol. 121, no. 15, pp. 108–112, 2009. View at Google Scholar
  113. H. L. Fehm, W. Kern, and A. Peters, “Chapter 7: the selfish brain: competition for energy resources,” Progress in Brain Research, vol. 153, pp. 129–140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  114. J. Wahren, K. Ekberg, E. Fernqvist-Forbes, and S. Nair, “Brain substrate utilisation during acute hypoglycaemia,” Diabetologia, vol. 42, no. 7, pp. 812–818, 1999. View at Publisher · View at Google Scholar · View at Scopus
  115. A. Silvani, V. Asti, C. Berteotti et al., “Sleep-related brain activation does not increase the permeability of the blood-brain barrier to glucose,” Journal of Cerebral Blood Flow and Metabolism, vol. 25, no. 8, pp. 990–997, 2005. View at Publisher · View at Google Scholar · View at Scopus
  116. B. Brooks, P. A. Cistulli, M. Borkman et al., “Obstructive sleep apnea in obese noninsulin-dependent diabetic patients: effect of continuous positive airway pressure treatment on insulin responsiveness,” Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 6, pp. 1681–1685, 1994. View at Google Scholar · View at Scopus
  117. B. G. Cooper, J. E. S. White, L. A. Ashworth, K. G. M. M. Alberti, and G. J. Gibson, “Hormonal and metabolic profiles in subjects with obstructive sleep apnea syndrome and the acute effects of nasal continuous positive airway pressure (CPAP) treatment,” Sleep, vol. 18, no. 3, pp. 172–179, 1995. View at Google Scholar · View at Scopus
  118. S. Saarelainen, J. Lahtela, and E. Kallonen, “Effect of nasal CPAP treatment on insulin sensitivity and plasma leptin,” Journal of Sleep Research, vol. 6, no. 2, pp. 146–147, 1997. View at Google Scholar · View at Scopus
  119. I. A. Harsch, S. P. Schahin, M. Radespiel-Tröger et al., “Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 169, no. 2, pp. 156–162, 2004. View at Publisher · View at Google Scholar · View at Scopus
  120. H. A. Hassaballa, A. Tulaimat, J. J. Herdegen, and B. Mokhlesi, “The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea,” Sleep and Breathing, vol. 9, no. 4, pp. 176–180, 2005. View at Publisher · View at Google Scholar · View at Scopus
  121. L. Czupryniak, J. Loba, M. Pawlowski, D. Nowak, and P. Bialasiewicz, “Treatment with continuous positive airway pressure may affect blood glucose levels in nondiabetic patients with obstructive sleep apnea syndrome,” Sleep, vol. 28, no. 5, pp. 601–603, 2005. View at Google Scholar · View at Scopus
  122. A. R. Babu, J. Herdegen, L. Fogelfeld, S. Shott, and T. Mazzone, “Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea,” Archives of Internal Medicine, vol. 165, no. 4, pp. 447–452, 2005. View at Publisher · View at Google Scholar · View at Scopus
  123. M. I. Trenell, J. A. Ward, B. J. Yee et al., “Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome,” Diabetes, Obesity and Metabolism, vol. 9, no. 5, pp. 679–687, 2007. View at Publisher · View at Google Scholar · View at Scopus
  124. S. R. Coughlin, L. Mawdsley, J. A. Mugarza, J. P. H. Wilding, and P. M. A. Calverley, “Cardiovascular and metabolic effects of CPAP in obese males with OSA,” European Respiratory Journal, vol. 29, no. 4, pp. 720–727, 2007. View at Publisher · View at Google Scholar · View at Scopus
  125. S. D. West, D. J. Nicoll, T. M. Wallace, D. R. Matthews, and J. R. Stradling, “Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes,” Thorax, vol. 62, no. 11, pp. 969–974, 2007. View at Publisher · View at Google Scholar · View at Scopus
  126. Z. Dorkova, D. Petrasova, A. Molcanyiova, M. Popovnakova, and R. Tkacova, “Effects of continuous positive airway pressure on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome,” Chest, vol. 134, no. 4, pp. 686–692, 2008. View at Publisher · View at Google Scholar · View at Scopus
  127. M. Pallayova, V. Donic, and Z. Tomori, “Beneficial effects of severe sleep apnea therapy on nocturnal glucose control in persons with type 2 diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 81, no. 1, pp. e8–e11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  128. S. P. Schahin, T. Nechanitzky, C. Dittel et al., “Long-term improvement of insulin sensitivity during CPAP therapy in the obstructive sleep apnoea syndrome,” Medical Science Monitor, vol. 14, no. 3, pp. CR117–CR121, 2008. View at Google Scholar · View at Scopus
  129. A. Dawson, S. L. Abel, R. T. Loving et al., “CPAP therapy of obstructive sleep apnea in type 2 diabetics improves glycemic control during sleep,” Journal of Clinical Sleep Medicine, vol. 4, no. 6, pp. 538–543, 2008. View at Google Scholar · View at Scopus
  130. B. Brooks, P. A. Cistulli, M. Borkman et al., “Obstructive sleep apnea in obese noninsulin-dependent diabetic patients: effect of continuous positive airway pressure treatment on insulin responsiveness,” Journal of Clinical Endocrinology and Metabolism, vol. 79, no. 6, pp. 1681–1685, 1994. View at Google Scholar · View at Scopus
  131. K. Chin, K. Shimizu, T. Nakamura et al., “Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy,” Circulation, vol. 100, no. 7, pp. 706–712, 1999. View at Google Scholar · View at Scopus
  132. M. S. M. Ip, K. S. L. Lam, C.-M. Ho, K. W. T. Tsang, and W. Lam, “Serum leptin and vascular risk factors in obstructive sleep apnea,” Chest, vol. 118, no. 3, pp. 580–586, 2000. View at Google Scholar · View at Scopus
  133. E. Lindberg, C. Berne, A. Elmasry, J. Hedner, and C. Janson, “CPAP treatment of a population-based sample-what are the benefits and the treatment compliance?” Sleep Medicine, vol. 7, no. 7, pp. 553–560, 2006. View at Publisher · View at Google Scholar · View at Scopus
  134. A. N. Vgontzas, E. Zoumakis, E. O. Bixler et al., “Selective effects of CPAP on sleep apnoea-associated manifestations,” European Journal of Clinical Investigation, vol. 38, no. 8, pp. 585–595, 2008. View at Publisher · View at Google Scholar · View at Scopus
  135. A. Sharafkhaneh, J. Garcia, H. Sharafkhaneh et al., “Insulin sensitivity in obstructive sleep apnea and effect of CPAP therapy,” Proceedings of the American Thoracic Society, vol. 3, 2006, abstract A733. View at Google Scholar
  136. G. Fahed, M. Boque, A. Torres-Palacios et al., “Effect of continuous positive airway pressure (CPAP) on insulin resistance and aspirin responsiveness,” American Thoracic Society, 2006, abstract A732. View at Google Scholar
  137. M. Pallayova, D. Donic, V. Donicova et al., “Effect of continuous positive airway pressure on nocturnal glucose levels in type 2 diabetics with sleep apnea: results of continuous glucose monitoring,” Sleep Medicine, vol. 7, supplement, p. S50, 2006. View at Google Scholar