|
| Study | Methods | Study type | Success rate | Pre-op | Intra-op |
|
| Adil et al. [46] | 305 patients (1997–2007) | Retrospective case series | 100% success | Pre-op sestamibi | IOPTH gamma probe |
| Krausz et al. [47] | 541 patients | Prospective cohort study | 97% success | Pre-op sestamibi scan or ultrasound | IOPTH |
| Sevinç et al. [48] | 56 patients (25 MIP, 31 MIRP) | Prospective study | Similar outcomes | Pre-op sestamibi | IOPTH in MIP gamma probe in MIRP |
| Sugino et al. [49] | 167 patients (80 IOPTH monitoring, 87 without IOPTH monitoring) | Prospective study | 97% versus 93% | Pre-op sestamibi scan, ultrasound, or CT scan | |
| Fouquet et al. [50] | 200 patients | Prospective study | 72% success 28% converted to open | Pre-op sestamibi scan or ultrasound | IOPTH |
| Hessman et al. [51] | 143 patients (75 MIP, 68 VAP) | Multicenter prospective randomized control trial | Similar outcomes (conversion rate, pain), VAP longer | Pre-op sestamibi scan | IOPTH |
| Slepavicius et al. [52] | 48 patients (24-focused exploration) | Prospective randomized control trial | Similar outcomes | Pre-op sestamibi scan or ultrasound | IOPTH |
| Shindo et al. [53] | 186 patients | Prospective study (historical cohort) | 95% success | Pre-op sestamibi scan or ultrasound | IOPTH |
| Shindo and Rosenthal [54] | 88 patients | Retrospective review | 91% success | Pre-op sestamibi scan or ultrasound | IOPTH |
| Rubello et al. [55] | 452 patients 344 MIRP | Prospective study | 93% success | Pre-op sestamibi scan or ultrasound | IOPTH gamma probe |
| Lindekleiv et al. [56] | 47 patients | Retrospective study | 97% success | Pre-op sestamibi scan | IOPTH |
| Aarum et al. [57] | 50 patients 23 MIP, 26 conventional | Prospective randomized control trial | 96% versus 94% | Pre-op sestamibi and ultrasound | IOPTH |
| Tang et al. [58] | 202 patients 50 MIP, 152 open | Retrospective study | Improved quality of life | | |
| Politz et al. [59] | 152 patients (118 MIP, 34 open) | Retrospective study | 98% success | Pre-op sestamibi scan | Intra-op gamma probe |
| Pang et al. [60] | 500 patients prospective | Prospective study | 97.4% success | Pre-op sestamibi scan + ultrasound for incision placement | |
| Soon et al. [61] | 699 patients | Retrospective study | | | IOPTH (not used as management aid) |
| Mihai et al. [62] | 298 patients 182-sestamibi 150-MIP | Prospective study | 97.3% success | Pre-op sestamibi scan | |
| Caudle et al. [63] | 140 patients | Prospective study | 96% success | Pre-op sestamibi | Intra-op gamma probe, frozen section |
| Alfadda et al. [64] | 55 patients | Retrospective study | 93% success | | |
| Carling et al. [43] | 441 patients | Prospective case series | 10% conversion to GA (thyroid exploration/conversion to open exploration/patient discomfort) | Pre-op sestamibi scan or ultrasound | IOPTH |
| Barczynski et al. [65] | 60 patients 30 MIP, 30 VAP | Prospective randomized control trial | 97% success in both groups, VAP with decreased pain & need for analgesia | Pre-op sestamibi and ultrasound | IOPTH |
| Cohen et al. [66] | 130 patients | Retrospective review | 98.6% success | Pre-op sestamibi scan and/or ultrasound | IOPTH |
| Ollila et al. [67] | 77 patients | Retrospective review | 96% success | Pre-op sestamibi scan | Intra-op gamma probe, selective frozen section |
| Miccoli et al. [68] | 51 patients 26-RA, 25-GA | Prospective randomized control trial | Decreased operative time and post-op need for analgesia with RA | Pre-op sestamibi scan and ultrasound | IOPTH |
| Mekel et al. [69] | 146 patients 84 MIP (79%) | Prospective study | | Pre-op sestamibi scan or ultrasound | IOPTH |
| Grant et al. [70] | 1361 patients | Retrospective review | 54% open exploration 44% MIP (2% conversion) | | |
| Rubello et al. [71] | 268 patients | Retrospective review | 96.8% success | Pre-op sestamibi and/or ultrasound | IOPTH |
| Bergenfelz et al. [72] | 50 patients 25-MIVAP, 25-open | Prospective randomized control trial | Decreased operating time with MIP | Pre-op sestamibi scan | IOPTH |
|
