The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
Table 4
The influence of cigarette smoking on total cholesterol level (CHOLT) and intima-media thickness (IMT) in men with particular genotype or allele of −786T/C polymorphism.
Genotype/allele
Parameter
Smokers
Non-smokers
-value*
−786CC
CHOLT (mmol/L) Left IMT (cm) Right IMT (cm)
5.66 0.55 0.52
4.85 0.53 0.5
0.01 0.81 0.96
−786TC
CHOLT (mmol/L) Left IMT (cm) Right IMT
5.74 0.55 0.56
5.3 0.54 0.55
0.03 0.47 0.94
−786TT
CHOLT (mmol/L) Left IMT (cm) Right IMT (cm)
5.28 0.61 0.6
5.08 0.59 0.58
0.47 0.57 0.5
−786C (CC + TC)
CHOLT (mmol/L) Left IMT (cm) Right IMT (cm)
5.73 0.55 0.56
5.27 0.54 0.54
0.003 0.41 0.84
−786T (TT + TC)
CHOLT (mmol/L) Left IMT (cm) Right IMT (cm)
5.57 0.56 0.57
5.28 0.55 0.56
0.06 0.61 0.69
Results expressed as mean values. Abbreviations: CHOLT: total cholesterol level. IMT: intima-media thickness of carotid arteries.
*
-value calculated in the Mann-Whitney test.
