Moderate Weight Reduction in an Outpatient Obesity Intervention Program Significantly Reduces Insulin Resistance and Risk Factors for Cardiovascular Disease in Severely Obese Adolescents

Table 2

Metabolic characteristics before and after participation in the obesity intervention program. Data are shown as means ± SD.

	Before treatment	After treatment	𝑃
Fasting insulin (μU/mL)	28.3±16.5	23.8±10.6	<0.03
Peak insulin (μU/mL)	232.7±132.4	179.2±73.3	<0.006
HOMA	6.3±4.2	4.9±2.4	<0.03
Fasting glucose (mmol/L)	4.7±0.6	4.7±0.5	n.s.
Peak glucose (mmol/L)	6.9±1.4	6.3±1.4	<0.03
Total cholesterol (mmol/L)	4.5±0.9	4.1±0.9	<0.0001
HDL cholesterol (mmol/L)	1.1±0.2	0.9±0.2	<0.002
LDL cholesterol (mmol/L)	2.9±0.8	2.5±0.7	<0.004
Triglycerides (mmol/L)	1.3±0.6	1.2±0.5	n.s.