The Involvement of Ser1898 of the Human L-Type Calcium Channel in Evoked Secretion
Figure 1
Membrane targeting of α 11.2 and α 11.2/S1898A to the membrane. (a) Schematic view of the α 11.2 pore forming subunit of . (b) A comparison of the protein kinase A (PKA) consensus sequence of the highly conserved Ser located at the distal C-terminal of α 11.2 of various species. (c) The human GFP-α 11.2 (7 ng/oocyte) and the GFP-α 11.2/S1898A (7 ng/oocyte) were injected into Xenopus laevis oocytes together with the β2b (2.5 ng/oocyte) and α2δ (5 ng/oocyte). Five days later the oocytes were imaged by confocal microscopy. Membrane targeting and expression of the channels to the membrane were determined by calculating the pixel/area.
