Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity

Figure 7

Histopathology of cardiac tissue.

(a) Normal Heart H and E 20x

(b) ISO (100 mg/kg) treated rat: moderate to severe cardiomyopathy indicating myocyte degeneration, fibrous tissue proliferation and necrotic foci. H and E 20x

(c) ISO + T₃ treated rats: myocardial tissue shows reduced inflammatory cell infiltration, no evidence of myonecrosis tends to revert normalcy. H and E 20x

(d) No changes noticed in myocardial tissue treated alone with T₃ at 3 μg/kg

(e) ISO (100 mg/kg): fibrous tissue proliferation in myocardial tissue Massion’s Trichrome 20x