Medical Therapy of Acromegaly

Table 2

Side-effects.

	Somatostatin analogues	Dopamine agonists	Pegvisomant
Often	Erythema at injection site	Nausea/vomiting	Headache
	Swelling at injection site	Headache	Vertigo
	Reduced appetite	Vertigo	Somnolence/asthenia
	Nausea/vomiting	Asthenia	Tremor
	Abdominal discomfort	Diarrhoea/constipation	Diarrhoea/constipation
	Bloating	Vasospasm	Nausea/vomiting/bloating
	Diarrhoea	Oedema	Sweating/pruritus
	Gallstones	Sleeping disorders	Hypercholesterolemia
	Reduced glucose tolerance		Hyperglycaemia
			Weight increase
			Hypertension
			Lipohypertrophy
			Abnormal liver function tests
			Pain at injection site
Rare	Alopecia	Orthostatic dysregulation	Thrombocytopenia
	Skin allergies	Psychomotoric disturbances	Leukocytopenia/leukocytosis
	Bradycardia	Visual hallucination	Hyperaesthesia
	Pancreatitis	Psychosis	Narcolepsy
	Reversible acute hepatitis	Retroperitoneal fibrosis	Visual disturbances
	Vitamin B12 deficiency	Valvular dysfunction	m. Meniere
	Abnormal liver function tests	Abnormal liver function tests	Dyspnoea
			Hematuria/proteinuria/polyuria
			Arthralgia/myalgia
			Hypertriglyceridaemia
			Hypoglycaemia
			Fever
			Sleeping disturbances