Microarchitecture, but Not Bone Mechanical Properties, Is Rescued with Growth Hormone Treatment in a Mouse Model of Growth Hormone Deficiency

Figure 2

Bone macrostructural results. From top to bottom, the rows display the whole femur, the femur cross-section (CSA), the whole vertebra, and cubes of vertebral trabecular bone. For the whole femur, the animal with the median femoral length in each group is displayed, and this same animal’s femur cross-section (at the shaft midpoint) is shown in the second row. For the whole vertebra, the mouse with the median vertebral body height in each group is shown, and the animal with the median BV/TV in each group is depicted in the bottom row. GH sufficient (GHS), GH deficient (GHD), early treatment (early; daily GH injections from age 21 to 60 days), late treatment (late; daily GH injections from age 35 to 60 days), and saline control (Saline; daily saline injections from age 21 to 60 days).