Microarchitecture, but Not Bone Mechanical Properties, Is Rescued with Growth Hormone Treatment in a Mouse Model of Growth Hormone Deficiency

Table 2

Vertebral trabecular microarchitectural parameters including bone volume ratio (BV/TV), connectivity density (Conn.D), structure model index (SMI), trabecular number (Tb.N), trabecular separation (Tb.Sp), and trabecular thickness (Tb.Th) in GH-sufficient (GHS), GH deficient (GHD), early treatment (early; daily GH injections from age 21 to 60 days), late treatment (late; daily GH injections from age 35 to 60 days), and saline control (saline; daily saline injections from age 21 to 60 days). Mean and standard errors are reported, and the coefficient of varation (CV%). *𝑃≤0.05, **𝑃≤0.001 versus GHS, ⁺𝑃≤0.05, ⁺⁺𝑃≤0.001 versus GHD.

Group	BV/TV (%)	Conn.D; (1/mm^3)	SMI	Tb.N; (1/mm)	Tb.Sp; (mm)	Th.Th; (mm)
GHS	25.29±1.05	363.8±22.3	0.79±0.08	5.53±0.16	0.167±0.006	0.0512±0.0010
GHD	20.12±1.38 *	358.7±40.1	1.33±0.11 *	5.84±0.21	0.160±0.007	0.0416±0.0009 **
Early	25.14±1.24^+	358.2±21.6	0.91±0.10^+	6.12±0.16	0.147±0.005	0.0473±0.0008^*++
Late	22.95±0.99	350.7±20.5	1.09±0.09	6.05±0.19	0.151±0.005	0.0452±0.0009 **
Saline	21.93±1.76	308.9±22.7	1.23±0.11	6.10±0.26	0.150±0.007	0.0429±0.0015
CV%	16.7%	22.1%	27.7%	9.8%	6.7%	11.7%