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International Journal of Endocrinology
Volume 2012, Article ID 296368, 9 pages
http://dx.doi.org/10.1155/2012/296368
Research Article

Analysis of Insulin in Human Breast Milk in Mothers with Type 1 and Type 2 Diabetes Mellitus

1Biochemistry and Molecular Biology, School of Biomedical and Chemical Sciences, Faculty of Life and Physical Sciences, The University of Western Australia, UWA M310, 35 Stirling Highway, Crawley, WA 6009, Australia
2Clinical Services, Royal Perth Hospital, GPO Box X2213, Perth, WA 6001, Australia
3Obstetrics and Gynaecology, School of Women’s and Infant’s Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, WA 6008, Australia

Received 15 September 2011; Revised 23 November 2011; Accepted 8 December 2011

Academic Editor: Stuart Tobet

Copyright © 2012 T. J. Whitmore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Koldovský, “Hormones in Milk,” Vitamins & Hormones, vol. 50, pp. 77–149, 1995. View at Publisher · View at Google Scholar
  2. J. K. Kulski and P. E. Hartmann, “Milk insulin, GH and TSH: relationship to changes in milk lactose, glucose and protein during lactogenesis in women,” Endocrinologia Experimentalis, vol. 17, no. 3-4, pp. 317–326, 1983. View at Google Scholar · View at Scopus
  3. M. Tiittanen, J. Paronen, E. Savilahti et al., “Dietary insulin as an immunogen and tolerogen,” Pediatric Allergy and Immunology, vol. 17, no. 7, pp. 538–543, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Shehadeh, E. Khaesh-Goldberg, R. Shamir et al., “Insulin in human milk: postpartum changes and effect of gestational age,” Archives of Disease in Childhood, vol. 88, no. 3, pp. F214–F216, 2003. View at Google Scholar · View at Scopus
  5. G. G. Briggs, R. K. Freeman, and S. J. Yaffe, Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 7th edition, 2005.
  6. T. W. Hale, Medications and Mothers' Milk, Pharmasoft, Amarillo, Tex, USA, 12th edition, 2006.
  7. J. P. Spencer, L. S. Gonzalez III, and D. J. Barnhart, “Medications in the breast-feeding mother,” American Family Physician, vol. 64, no. 1, pp. 119–126, 2001. View at Google Scholar · View at Scopus
  8. J. P. Buts, N. De Keyser, and C. Dive, “Intestinal development in the suckling rat: effect of insulin on the maturation of villus and crypt cell functions,” European Journal of Clinical Investigation, vol. 18, no. 4, pp. 391–398, 1988. View at Google Scholar · View at Scopus
  9. S. Marandi, N. De Keyser, A. Saliez et al., “Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases,” American Journal of Physiology, vol. 280, no. 2, pp. G229–G240, 2001. View at Google Scholar · View at Scopus
  10. T. Kinouchi, K. Koizumi, T. Kuwata, and T. Yajima, “Milk-borne insulin with trypsin inhibitor in milk induces pancreatic amylase development at the onset of weaning in rats,” Journal of Pediatric Gastroenterology and Nutrition, vol. 30, no. 5, pp. 515–521, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. R. J. Shulman, “Oral insulin increases small intestinal mass and disaccharidase activity in the newborn miniature pig,” Pediatric Research, vol. 28, no. 2, pp. 171–175, 1990. View at Google Scholar · View at Scopus
  12. I. P. Georgiev, T. M. Georgieva, M. Pfaffl, H. M. Hammon, and J. W. Blum, “Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves,” Journal of Endocrinology, vol. 176, no. 1, pp. 121–132, 2003. View at Publisher · View at Google Scholar
  13. R. J. Shulman, D. R. Tivey, I. Sunitha, M. A. Dudley, and S. J. Henning, “Effect of oral insulin on lactase activity, mRNA, and posttranscriptional processing in the newborn pig,” Journal of Pediatric Gastroenterology and Nutrition, vol. 14, no. 2, pp. 166–172, 1992. View at Google Scholar
  14. N. Shehadeh, I. Sukhotnik, and R. Shamir, “Gastrointestinal tract as a target organ for orally administered insulin,” Journal of Pediatric Gastroenterology and Nutrition, vol. 43, no. 3, pp. 276–281, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. A. DeFronzo, International Textbook of Diabetes Mellitus, John Wiley & Sons, Hoboken, NJ, USA, 3rd edition, 2004.
  16. R. M. Bergenstal, “Effective insulin therapy,” in International Textbook of Diabetes Mellitus, R. A. DeFronzo, Ed., pp. 995–1015, John Wiley & Sons, Hoboken, NJ, USA, 3rd edition, 2004. View at Google Scholar
  17. S. C. L. Gough, “A review of human and analogue insulin trials,” Diabetes Research and Clinical Practice, vol. 77, no. 1, pp. 1–15, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. A. H. Heald, B. Bhattacharya, H. Cooper et al., “Most commercial insulin assays fail to detect recombinant insulin analogues,” Annals of Clinical Biochemistry, vol. 43, no. 4, pp. 306–308, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Chaillous, H. Lefèvre, C. Thivolet et al., “Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial,” The Lancet, vol. 356, no. 9229, pp. 545–549, 2000. View at Google Scholar
  20. D. A. Schatz, D. G. Rogers, and B. H. Brouhard, “Prevention of insulin-dependent diabetes mellitus: an overview of three trials,” Cleveland Clinic Journal of Medicine, vol. 63, no. 5, pp. 270–274, 1996. View at Google Scholar · View at Scopus
  21. S. G. A. Gimeno and J. M. P. De Souza, “IDDM and milk consumption. a case-control study in São Paulo, Brazil,” Diabetes Care, vol. 20, no. 8, pp. 1256–1260, 1997. View at Google Scholar · View at Scopus
  22. E. Savilahti and K. M. Saarinen, “Early infant feeding and type 1 diabetes,” European Journal of Nutrition, vol. 48, no. 4, pp. 243–249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. R. M. Viner, P. C. Hindmarsh, B. Taylor, and T. J. Cole, “Childhood body mass index (BMI), breastfeeding and risk of type 1 diabetes: findings from a longitudinal national birth cohort,” Diabetic Medicine, vol. 25, no. 9, pp. 1056–1061, 2008. View at Publisher · View at Google Scholar
  24. J. Schrezenmeir and A. Jagla, “Milk and diabetes,” Journal of the American College of Nutrition, vol. 19, no. 2, supplement, pp. 176S–190S, 2000. View at Google Scholar · View at Scopus
  25. P. G. Arthur, M. Smith, and P. E. Hartmann, “Milk lactose, citrate, and glucose as markers of lactogenesis in normal and diabetic women,” Journal of Pediatric Gastroenterology and Nutrition, vol. 9, no. 4, pp. 488–496, 1989. View at Google Scholar · View at Scopus
  26. S. Lindpointer, S. Korsatko, G. Kohler et al., “Use of the site of subcutaneous insulin adminsitration for the measurement of glucose in patients with type 1 diabetes,” Diabetes Care, vol. 33, pp. 595–601, 2010. View at Google Scholar
  27. T. Lindström, C. A. Hedman, and H. J. Arnqvist, “Use of a novel double-antibody technique to describe the pharmacokinetics of rapid-acting insulin analogs,” Diabetes Care, vol. 25, no. 6, pp. 1049–1054, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Lucas, J. A. H. Gibbs, R. L. J. Lyster, and J. D. Baum, “Creamatocrit: simple clinical technique for estimating fat concentration and energy value of human milk,” British Medical Journal, vol. 1, no. 6119, pp. 1018–1020, 1978. View at Google Scholar · View at Scopus
  29. M. C. Neville, W. W. Hay, and P. Fennessey, “Physiological significance of the concentration of human milk glucose,” Protoplasma, vol. 159, no. 2-3, pp. 118–128, 1990. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Nowak and J. Nowak, “Changes of insulin concentration in colostrum and milk of women, cows and sows,” Acta Physiologica Polonica, vol. 40, no. 4, pp. 349–355, 1989. View at Google Scholar · View at Scopus
  31. L. M. Powell, S. C. Wallis, R. J. Pease, Y. H. Edwards, T. J. Knott, and J. Scott, “A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine,” Cell, vol. 50, no. 6, pp. 831–840, 1987. View at Google Scholar · View at Scopus
  32. T. M. Devlin, Textbook of Biochemistry With Clinical Correlations, Wiley-Liss, New York, NY, USA, 5th edition, 2002.
  33. A. M. Bonser and P. Garcia-Webb, “C-peptide measurement: methods and clinical utility,” Critical Reviews in Clinical Laboratory Sciences, vol. 19, no. 4, pp. 297–352, 1984. View at Google Scholar · View at Scopus
  34. S. Madsbad, G. F. Bottazzo, A. G. Cudworth, B. Dean, O. K. Faber, and C. Binder, “Islet cell antibodies and beta cell function in insulin dependent diabetics,” Diabetologia, vol. 18, no. 1, pp. 45–47, 1980. View at Google Scholar
  35. R. G. Jensen, Handbook of Milk Composition, Academic Press, San Diego, Calif, USA, 1995.
  36. W. A. Banks, “The source of cerebral insulin,” European Journal of Pharmacology, vol. 490, no. 1–3, pp. 5–12, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Wang, Z. Liu, G. Li, and E. J. Barrett, “The vascular endothelial cell mediates insulin transport into skeletal muscle,” American Journal of Physiology, vol. 291, no. 2, pp. E323–E332, 2006. View at Publisher · View at Google Scholar
  38. K. J. Hunt and K. L. Schuller, “The increasing prevalence of diabetes in pregnancy,” Obstetrics and Gynecology Clinics of North America, vol. 34, no. 2, pp. 173–199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Sesti, M. Federici, D. Lauro, P. Sbraccia, and R. Lauro, “Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms,” Diabetes/Metabolism Research and Reviews, vol. 17, no. 5, pp. 363–373, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. M. B. Jackson, C. J. Lammi-Keefe, R. G. Jensen, S. C. Couch, and A. M. Ferris, “Total lipid and fatty acid composition of milk from women with and without insulin-dependent diabetes mellitus,” American Journal of Clinical Nutrition, vol. 60, no. 3, pp. 353–361, 1994. View at Google Scholar · View at Scopus
  41. B. Mosinger, Z. Placer, and O. Koldovsky, “Passage of insulin through the wall of the gastro-intestinal tract of the infant rat,” Nature, vol. 184, 16, pp. 1245–1246, 1959. View at Google Scholar
  42. S. Deshpande and M. W. Platt, “The investigation and management of neonatal hypoglycaemia,” Seminars in Fetal and Neonatal Medicine, vol. 10, no. 4, pp. 351–361, 2005. View at Publisher · View at Google Scholar · View at Scopus