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International Journal of Endocrinology
Volume 2012, Article ID 324835, 6 pages
http://dx.doi.org/10.1155/2012/324835
Research Article

Clinical Presentation of Klinefelter's Syndrome: Differences According to Age

1Servicio de Endocrinología y Metabolismo, Unidad Asistencial “Dr. César Milstein”, Buenos Aires, Argentina
2Sección Endocrinología, Crecimiento y Desarrollo, Departamento de Pediatría, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
3División de Endocrinología, Hospital de Niños Dr. Ricardo Gutiérrez and, Centro de Investigaciones Endocrinológicas (CEDIE, CONICET), Buenos Aires, Argentina
4Servicio de Endocrinología, Metabolismo y Medicina Nuclear, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
5Consultorio de Endocrinología, Centro Médico Haedo, Haedo, Argentina
6Sección Andrología, División Endocrinología, Hospital Durand, Buenos Aires, Argentina

Received 29 July 2011; Accepted 8 October 2011

Academic Editor: Ana Claudia Latronico

Copyright © 2012 Néstor Pacenza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [33 citations]

The following is the list of published articles that have cited the current article.

  • Robert D. Oates, “The natural history of endocrine function and spermatogenesis in Klinefelter syndrome: what the data show,” Fertility And Sterility, vol. 98, no. 2, pp. 266–273, 2012. View at Publisher · View at Google Scholar
  • Bruna J. Tincani, Gil Guerra Jr., Bruno R. Mascagni, Roberto D. P. Pinto, Guilherme Guaragna-Filho, Carla C. T. S. Castro, Letícia E. Sewaybricker, Nilma L. Viguetti-Campos, Antonia P. Marques-de-Faria, and Andréa T. Maciel-Guerra, “Klinefelter syndrome: An unusual diagnosis in pediatric patients,” Jornal de Pediatria, vol. 88, no. 4, pp. 323–327, 2012. View at Publisher · View at Google Scholar
  • Marie Lindhardt Johansen, Casper P. Hagen, Trine Holm Johannsen, Katharina M. Main, Jean-Yves Picard, Anne Jørgensen, Ewa Rajpert-De Meyts, and Anders Juul, “Anti-Müllerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development,” International Journal of Endocrinology, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Richard N. Yu, Laurie E. Cohen, Leena Nahata, and Ilina Rosoklija, “Klinefelter Syndrome: Are We Missing Opportunities for Early Detection?,” Clinical Pediatrics, vol. 52, no. 10, pp. 936–941, 2013. View at Publisher · View at Google Scholar
  • Joachim Wistuba, Steffi Werler, and Lars Lewejohann, “Mouse Models for the Exploration of Klinefelter’s Syndrome,” Animal Models for the Study of Human Disease, pp. 759–784, 2013. View at Publisher · View at Google Scholar
  • L. Ibanez Toda, and A. Turon Vinas, “Atypical presentation of Klinefelter syndrome,” Anales De Pediatria, vol. 79, no. 2, pp. 112–115, 2013. View at Publisher · View at Google Scholar
  • Min Kang, Chan Jae Lee, Il Tae Hwang, Kwanseop Lee, and Min Jae Kang, “Prepubertal unilateral gynecomastia in the absence of endocrine abnormalities,” Annals of Pediatric Endocrinology & Metabolism, vol. 19, no. 3, pp. 159, 2014. View at Publisher · View at Google Scholar
  • Shanlee M. Davis, Alan D. Rogol, and Judith L. Ross, “Testis Development and Fertility Potential in Boys with Klinefelter Syndrome,” Endocrinology and Metabolism Clinics of North America, 2015. View at Publisher · View at Google Scholar
  • Amr Hodhod, Florence Umurangwa, and Mohamed El-Sherbiny, “Prepubertal diagnosis of Klinefelter syndrome due to penoscrotal malformations: Case report and review of literature,” Cuaj-Canadian Urological Association Journal, vol. 9, no. 5-6, pp. E333–E336, 2015. View at Publisher · View at Google Scholar
  • Leena Nahata, Richard N. Yu, Shalender Bhasin, and Laurie E. Cohen, “Management of testosterone therapy in adolescents and young men with hypogonadism: are we following adult clinical practice guidelines?,” Journal Of Pediatric Endocrinology & Metabolism, vol. 28, no. 5-6, pp. 635–640, 2015. View at Publisher · View at Google Scholar
  • Gies, and De Schepper, “Children and adolescents with Klinefelter syndrome: Testosterone substitution,” Tijdschrift voor Geneeskunde, vol. 71, no. 5, pp. 335–338, 2015. View at Publisher · View at Google Scholar
  • Leena Nahata, Richard N. Yu, Harriet J. Paltiel, Jeanne S. Chow, Tanya Logvinenko, Ilina Rosoklija, and Laurie E. Cohen, “Sperm Retrieval in Adolescents and Young Adults with Klinefelter Syndrome: A Prospective, Pilot Study,” The Journal of Pediatrics, 2015. View at Publisher · View at Google Scholar
  • Jens Fedder, Claus H. Gravholt, Stine Gry Kristensen, Niels Marcussen, Birte Engvad, Ann Mains Milton, and Claus Yding Andersen, “Testicular Sperm Sampling by Subcapsular Orchiectomy in Klinefelter Patients: A New Simplified Treatment Approach,” Urology, vol. 86, no. 4, pp. 744–750, 2015. View at Publisher · View at Google Scholar
  • Gunilla Jaeger, AnnCatrin Rojvik, and Britta Berglund, “Participation in society for people with a rare diagnosis,” Disability And Health Journal, vol. 8, no. 1, pp. 44–50, 2015. View at Publisher · View at Google Scholar
  • S. Davis, N. Lahlou, M. Bardsley, M.-C. Temple, K. Kowal, L. Pyle, P. Zeitler, and J. Ross, “Gonadal function is associated with cardiometabolic health in pre-pubertal boys with Klinefelter syndrome,” Andrology, 2016. View at Publisher · View at Google Scholar
  • Shanlee Davis, Susan Howell, Rebecca Wilson, Tanea Tanda, Judy Ross, Philip Zeitler, and Nicole Tartaglia, “Advances in the Interdisciplinary Care of Children with Klinefelter Syndrome,” Advances in Pediatrics, vol. 63, no. 1, pp. 15–46, 2016. View at Publisher · View at Google Scholar
  • Herman Tournaye, Csilla Krausz, and Robert D Oates, “Novel concepts in the aetiology of male reproductive impairment,” The Lancet Diabetes & Endocrinology, 2016. View at Publisher · View at Google Scholar
  • Manuel Nistal, and Pilar González-Peramato, “Entities Contributing to Infertility and Their Relationship to Oncogenic Risk,” Pathology of Testicular and Penile Neoplasms, pp. 49–67, 2016. View at Publisher · View at Google Scholar
  • Rebecca J. Bird, and Bradley J. Hurren, “Anatomical and clinical aspects of Klinefelter's syndrome,” Clinical Anatomy, vol. 29, no. 5, pp. 606–619, 2016. View at Publisher · View at Google Scholar
  • F. Paris, L. Gaspari, F. Mbou, P. Philibert, F. Audran, Y. Morel, A. Biason-Lauber, and C. Sultan, “Endocrine and molecular investigations in a cohort of 25 adolescent males with prominent/persistent pubertal gynecomastia,” Andrology, 2016. View at Publisher · View at Google Scholar
  • Stefano Stagi, Mariarosaria Di Tommaso, Cristina Manoni, Perla Scalini, Francesco Chiarelli, Alberto Verrotti, Elisabetta Lapi, Sabrina Giglio, Laura Dosa, and Maurizio de Martino, “Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome,” International Journal of Endocrinology, vol. 2016, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Seung Jin Han, Kyung-Soo Kim, Wonjin Kim, Jung Hee Kim, Yong-ho Lee, Ji Sun Nam, Ji A Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min-Hee Kim, Tae-Seo Sohn, Han Seok Choi, Seong Bin Hong, and Yoon-Sok Chung, “Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry,” Endocrinology and Metabolism, vol. 31, no. 4, pp. 598, 2016. View at Publisher · View at Google Scholar
  • Rebecca O'Donovan, and Birgit Völlm, “Klinefelter's syndrome and sexual offending - A literature review,” Criminal Behaviour and Mental Health, 2017. View at Publisher · View at Google Scholar
  • Hale Tuhan, Elçin Bora, Sezer Acar, Korcan Demir, Hüseyin Onay, Derya Erçal, Ece Böber, and Ayhan Abacı, “Identification of an AR mutation in klinefelter syndrome during evaluation for penoscrotal hypospadias,” Hormones, vol. 16, no. 3, pp. 313–317, 2017. View at Publisher · View at Google Scholar
  • Graciela Arébalo De Cross, Yamile Mocarbel, Marie C. Lebrethon, Albert Thiry, Albert Beckers, and Hernan Valdes-Socin, “Craniopharyngioma and Klinefelter syndrome during the pubertal transition: A diagnostic challenge,” Archivos Argentinos de Pediatria, vol. 115, no. 2, pp. e104–ee107, 2017. View at Publisher · View at Google Scholar
  • John K. Amory, and William J. Bremner, “Klinefelter Syndrome and Other Forms of Primary Testicular Failure,” Male Hypogonadism, pp. 187–196, 2017. View at Publisher · View at Google Scholar
  • Joachim Wistuba, Cristin Brand, Steffi Werler, Lars Lewejohann, and Oliver S. Damm, “Mouse Models for the Exploration of Klinefelter?s Syndrome,” Animal Models for the Study of Human Disease, pp. 621–649, 2017. View at Publisher · View at Google Scholar
  • Rosita A. Condorelli, Rossella Cannarella, Aldo E. Calogero, and Sandro La Vignera, “Evaluation of testicular function in prepubertal children,” Endocrine, 2018. View at Publisher · View at Google Scholar
  • M. W. Ragab, J.-F. Cremers, M. Zitzmann, E. Nieschlag, S. Kliesch, and J. Rohayem, “A history of undescended testes in young men with Klinefelter syndrome does not reduce the chances for successful microsurgical testicular sperm extraction,” Andrology, 2018. View at Publisher · View at Google Scholar
  • Pablo René Costanzo, Néstor Antonio Pacenza, Sergio Mario Aszpis, Sebastián Matías Suárez, Uriel Marcelo Pragier, Jorge Guillermo Stewart Usher, Miguel Vásquez Cayoja, Sergio Iturrieta, Silvia Elisa Gottlieb, Rodolfo Alberto Rey, and Pablo Knoblovits, “Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study,” BioMed Research International, vol. 2018, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • Hyo S. Lee, Shin Y. Kim, Bom Y. Lee, So Y. Park, Ah R. Oh, and Ju T. Seo, “Clinical, Hormonal, and Genetic Evaluation of Idiopathic Nonobstructive Azoospermia and Klinefelter Syndrome Patients,” Cytogenetic and Genome Research, vol. 153, no. 4, pp. 190–197, 2018. View at Publisher · View at Google Scholar
  • S. J. Winters, J. P. Moore, and B. J. Clark, “Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?,” Andrology, 2018. View at Publisher · View at Google Scholar
  • Shanlee M. Davis, and Judith L. Ross, “Klinefelter Syndrome,” Reference Module in Biomedical Sciences, 2018. View at Publisher · View at Google Scholar