Alpha Lipoic Acid for Symptomatic Peripheral Neuropathy in Patients with Diabetes: A Meta-Analysis of Randomized Controlled Trials

Table 1

Methodological quality assessment of the included intervention studies.

		Ziegler 1995 [15] ALADIN	Ruhnau 1999 [16] ORPIL	Ametov 2003 [17] SYDNEY	Ziegler 2006 [18] SYDNEY 2
(1)	Randomisation?	yes	yes	yes	yes
(2)	Concealment of allocation?	yes	yes	yes	yes
(3)	Patients blinded?	yes	yes	yes	yes
(4)	Doctors blinded?	yes	yes	yes	yes
(5)	Investigators blinded?	NO	NO	NO	NO
(6)	Groups comparable at baseline?	yes	yes	yes	yes
(7)	Follow-up complete of >80% of patients?	yes	yes	yes	yes
(8)	Intention-to-treat analysis?	yes	yes	yes	yes
	Level of evidence	1b	1b	1b	1b