A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation

Figure 3

Schematic representation of JAK/STAT signalling. Mechanisms through prolactin and growth hormone modulate beta-cell proliferation. These hormones via prolactin receptor activate JAK, which is able to phosphorylate STAT. After phosphorylation, two molecules of STAT bind together and translocate into the nuclei where elicit their transcriptional function.