Suppression of Aldosterone Synthesis and Secretion by Ca^𝟐+ Channel Antagonists

Table 1

The effects of dihydropyridine CCBs on dbcAMP- or KCl-induced expression of steroidogenic enzymes.

Dihydropyridine CCB	Type of affecting Ca^2+ channels	StAR	CYP11A1	3βHSD2	CYP21A2	CYP11B1	CYP11B2	STS	SULT2A1
Amlodipine	L, T	→	→	→	→			→	→
Azelnidipine	L, T	→	→	→	→	↓	↓	→	→
Benidipine	L, T					↓	↓
Efonidipine	L, T	↑	→	→	→	↓	↓	→	→
Isradipine	L, T	↑
Nifedipine	L	↑	→	→	→	↓	↓	→	→
Nitrendipine	L					↓	↓

dbcAMP: N⁶, 2′-O-dibutyryladenosine 3′, and 5′-cyclic monophosphate.