Suppression of Aldosterone Synthesis and Secretion by Ca^𝟐+ Channel Antagonists

Table 2

The effects of dihydropyridine CCBs on angiotensin II-induced expression of steroidogenic enzymes.

Dihydropyridine CCB	Type of affecting Ca^2+ channels	StAR	CYP11B1	CYP11B2
Amlodipine	L, T	→
Azelnidipine	L, T	↓	↓	↓
Benidipine	L, T		↓	↓
Cilnidipine	L, N		→	↓
Efonidipine	L, T	↑	↓	↓
Nifedipine	L	→	↓	↓
Nitrendipine	L		→	→