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International Journal of Endocrinology
Volume 2012 (2012), Article ID 540681, 7 pages
http://dx.doi.org/10.1155/2012/540681
Clinical Study

Serum FSH Levels in Coasting Programmes on the hCG Day and Their Clinical Outcomes in IVF ± ICSI Cycles

1Kamineni Fertility Centre, Kamineni Hospitals, King Koti, Hyderabad 500001, India
2Services of Gynecology and Obstetrics-Reproduction, The Bow Hospital, Chu de Nice, Route Saint Anton, 06200 Nice, France
3Centre for Reproductive Medicine-Barts and The London NHS Trust, London EC 1A 7BE, UK

Received 28 July 2011; Revised 12 October 2011; Accepted 17 October 2011

Academic Editor: Mario Maggi

Copyright © 2012 Srisailesh Vitthala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Coasting is the most commonly used strategy in prevention of severe OHSS. Serum FSH levels measurements during coasting may aid in optimizing the duration of coasting. Objective(s). To study live birth rates (LBRs), clinical pregnancy rates (CPRs), and optimal duration of coasting based on serum FSH levels on the hCG day. Materials and Methods. It is a retrospective study performed between 2005 and 2008 at Barts and The London Centre for Reproductive Medicine, NHS Trust, London, UK, on 349-coasted women undergoing controlled ovarian stimulation (COS) for IVF ± ICSI. The serum FSH level measurements on the hCG day during coasting programme were analysed to predict the LBR and CPR. Result(s). LBR and CPR were significantly higher when the FSH levels on the hCG day were >2.5 IU/L (LBR: 32.5%, P = 0.045 and CPR: 36.9%, P = 0.027) compared to FSH <2.5 IU/L. The optimal FSH cut-off level for LBR and CPR is 5.6 IU/L on the hCG day. The optimal cutoff for coasting is 4 days. Conclusion(s). Coasting may be continued as long as either serum FSH level is > 2.5 IU/L on the hCG day without compromising the LBR and CPR or to maximum of 4 days.