Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture

Figure 1

Schematic representation of independent significant associations between serum osteocalcin, adipokines, their ratios, renal status, and age in older patient with hip fracture. LR, leptin/resistin ratio; AR, adiponectin/resistin ratio, eGFR, estimated glomerular filtration rate. Bidirectional interactions exist between leptin and osteocalcin (positive), between resistin and osteocalcin (negative) and as a consequence between leptin/resistin ratio and osteocalcin and between adiponectin/resistin ratio and osteocalcin (both positive). Age is an independent determinant of circulating levels of resistin (positive association) and leptin (negative associations), whereas renal function (eGFR) is inversely associated with osteocalcin and leptin.