Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
Figure 2
Endocrine changes in C57Bl/6 and db/db mice following running or caloric restriction. For all graphs, asterisk (*) indicates significance at relative to sedentary C57Bl/6 mice fed ad libitum. Black diamonds (♦) represent significance at relative to sedentary db/db mice fed ad libitum. (a) Caloric restriction (CR) attenuates fasting hyperglycemia in db/db mice. (b) CR lowers circulating insulin concentrations in C57Bl/6 mice, and both running and CR reinstate normal insulin levels in db/db mice. (c) Although there is a trend towards reduced total cholesterol in runners, this did not reach statistical significance. (d) Serum triglycerides are elevated in db/db mice, but this elevation can be ameliorated following running or CR. (e) Serum leptin levels are increased in db/db mice across all conditions. (f) Running attenuates the elevated corticosterone levels observed in db/db mice. Abbreviations: wt = C57Bl/6; AL = ad libitum; CR = caloric restriction; RUN = wheel running; DB = db/db mice.
