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International Journal of Endocrinology
Volume 2012 (2012), Article ID 896736, 5 pages
http://dx.doi.org/10.1155/2012/896736
Clinical Study

Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study

13rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Montleartstrasse 37, 1160 Vienna, Austria
2Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
3Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
4Clinical Institute for Medical and Chemical Laboratory Diagnostic, General Hospital of Vienna, Vienna, Austria
5Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria

Received 30 October 2011; Accepted 23 January 2012

Academic Editor: Graziano Di Cianni

Copyright © 2012 Serdar Farhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Fetuin-A has been associated with gestational diabetes mellitus (GDM). We investigated fetuin-A levels during and after pregnancy in women with GDM. Fetuin-A measurements were performed in 10 women with GDM and 10 age and body mass index (BMI) matched healthy pregnant women. All women underwent an oral glucose tolerance test (OGTT) in and 3 months after gestation. Results. Fasting fetuin-A correlated with BMI in women with former GDM ( , ) but showed no association with parameters of glucose tolerance in women with GDM or post-GDM. GDM featured significantly lower insulin sensitivity and higher insulin and C-peptide secretion profiles compared to NGT during pregnancy ( ). Fasting and postprandial fetuin-A did not differ between groups, neither during nor after pregnancy. Conclusion. Fetuin-A is not influenced by glucose tolerance during or after pregnancy or acute glucose elevations following glucose ingestion in young women, but closely relates to BMI early postpartum.