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International Journal of Endocrinology
Volume 2012 (2012), Article ID 925143, 8 pages
Review Article

Chemical Methods to Induce Beta-Cell Proliferation

Chemical Biology Program, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA

Received 19 March 2012; Accepted 21 May 2012

Academic Editor: A. N. Balamurugan

Copyright © 2012 Amedeo Vetere and Bridget K. Wagner. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Weijun Shen, Matthew S. Tremblay, Vishal A. Deshmukh, Weidong Wang, Christophe M. Filippi, George Harb, You-qing Zhang, Anwesh Kamireddy, Janine E. Baaten, Qihui Jin, Tom Wu, Jonathan G. Swoboda, Charles Y. Cho, Jing Li, Bryan A. Laffitte, Peter McNamara, Richard Glynne, Xu Wu, Ann E. Herman, and Peter G. Schultz, “Small-Molecule Inducer of beta Cell Proliferation Identified by High-Throughput Screening,” Journal Of The American Chemical Society, vol. 135, no. 5, pp. 1669–1672, 2013. View at Publisher · View at Google Scholar
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  • Marta Szabat, and James D. Johnson, “Modulation of beta-Cell Fate and Function by TGF beta Ligands: A Superfamily With Many Powers,” Endocrinology, vol. 154, no. 11, pp. 3965–3969, 2013. View at Publisher · View at Google Scholar
  • Philippe A. Lysy, and Gordon C. Weir, “Making beta Cells from Adult Cells Within the Pancreas,” Current Diabetes Reports, vol. 13, no. 5, pp. 695–703, 2013. View at Publisher · View at Google Scholar
  • Amedeo Vetere, Amit Choudhary, Sean M. Burns, and Bridget K. Wagner, “Targeting the pancreatic β-cell to treat diabetes,” Nature Reviews Drug Discovery, 2014. View at Publisher · View at Google Scholar
  • M. Skrzypski, N. Khajavi, S. Mergler, D. Szczepankiewicz, P. A. Kolodziejski, D. Metzke, T. Wojciechowicz, M. Billert, K. W. Nowak, and M. Z. Strowski, “TRPV6 channel modulates proliferation of insulin secreting INS-1E beta cell line,” Biochimica Et Biophysica Acta-Molecular Cell Research, vol. 1853, no. 12, pp. 3202–3210, 2015. View at Publisher · View at Google Scholar
  • Brian P. Boerner, Nicholas M. George, Shakeel U.R. Mir, and Nora E. Sarvetnick, “WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability,” Endocrine Journal, vol. 62, no. 4, pp. 379–386, 2015. View at Publisher · View at Google Scholar
  • Mirjana Mihailović, Jelena Arambašić Јovanović, Aleksandra Uskoković, Nevena Grdović, Svetlana Dinić, Senka Vidović, Goran Poznanović, Ibrahim Mujić, and Melita Vidaković, “ Protective Effects of the Mushroom Lactarius deterrimus Extract on Systemic Oxidative Stress and Pancreatic Islets in Streptozotocin-Induced Diabetic Rats ,” Journal of Diabetes Research, vol. 2015, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Ercument Dirice, Deepika Walpita, Amedeo Vetere, Bennett C. Meier, Sevim Kahraman, Jiang Hu, Vlado Dančík, Sean M. Burns, Tamara J. Gilbert, David E. Olson, Paul A. Clemons, Rohit N. Kulkarni, and Bridget K. Wagner, “Inhibition of DYRK1A Stimulates Human β-Cell Proliferation,” Diabetes, vol. 65, no. 6, pp. 1660–1671, 2016. View at Publisher · View at Google Scholar
  • Zerihun Assefa, Astrid Lavens, Geert Stangé, Zhidong Ling, Sarah Akbib, Karine H. Hellemans, and Daniel Pipeleers, “Direct effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation,” American Journal of Physiology - Endocrinology and Metabolism, vol. 311, no. 4, pp. E698–E705, 2016. View at Publisher · View at Google Scholar