Clinical Study

Perioperative Endocrine Therapy for Patients with Cushing's Syndrome Undergoing Retroperitoneal Laparoscopic Adrenalectomy

Table 1

Patients’ characteristics before surgeries.

ItemsPatients’ information

Number82 patients
Age years (range, 18–53)
Gender ( [%])20 male (24.4%); 62 female (75.6%)
Diagnosis by CT or MRI ( [%])
 Single adrenal adenoma80 (97.6%)
 Multiple adrenal adenoma (unilateral)1 (1.2%)
 Bilateral adrenal adenoma1 (1.2%)
Time to diagnosis months (range, 1–61 months)
Blood pressure when admitted to hospital156/105 mmHg (range, 140~210/90~130 mmHg)
Hypokalemia ( value)68;  mmoL/L (range, 2.80–3.45 mmoL/L)
Fasting blood glucose greater than 6.9 mmoL/L58;  mmoL/L (range, 6.9–13.5 mmoL/L)
physiological fluctuationofcortisolAbsent in all patients
Serum cortisol on 8 AM  nmoL/L (range, 674.0–870.6 nmoL/L)
(normal, 147.3–609.3 nmoL/L)
24 hr urinary cortisol g/24 h (range, 497.6–1092.5  g/24 h)
(normal, 20.26–127.55  g/24 h)
Serum ACTH 8 AM  ng/L, (range, 0.05–0.8 ng/L)
(normal, 5.0–7.81 ng/L)
High dose dexamethasone suppression test (HDDST) No suppression in all 82 patients
Low dose dexamethasone suppression test (LDDST)No case of complete suppression (serum cortisol levels < 50 nmoL/L)
No suppression in 82 patients (>140 nmoL/L)