International Journal of Endocrinology / 2013 / Article / Tab 1

Clinical Study

Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus

Table 1

Comparison of demographic, anthropometric, biochemical parameters and sonographic findings in children, and adolescents between diabetic and control groups.

ParametersT1DM ( )
Mean ± SD or %
Controls ( )
Mean ± SD or %
P value

Age (years)12.0 (2.7)12.1 (3.3)0.426
Male (53.4%) (53.5%)0.812
BMI (kg/m2)20.9 (3.8)19.6 (3.4)0.155
SDS BMI*69.970.30.943
HbA1c (%)8.02 (1.52)4.12 (0.93)0.001
Glucose (mg/dL)143.4 (84.1)81.9 (10.3)0.001
Diabetes duration (years)5.42 (2.87)
Urea (mg/dL)29.65 (8.17)24.00 (4.16)0.001
Creatinine (mg/dL)0.70 (0.15)0.62 (0.17)0.134
eGFR (mL/min)132.1 (23.1)136.3 (14.4)0.529
CRP (mg/dL)0.84 (1.27)0.46 (0.52)0.304
Tchol (mg/dL)160.6 (20.1)157.4 (25.0)0.683
TG (mg/dL)72.00 (4.52)57.69 (17.03)0.060
HDL-C (mg/dL)59.13 (10.02)59.54 (6.97)0.803
LDL-C (mg/dL)90.91 (20.86)90.46 (24.65)0.952
ApoA1 (mg/dL)154.8 (18.3)149.2 (16.0)0.279
ApoB (mg/dL)65.33 (12.47)64.54 (14.25)0.856
WBC (cells/μL)6,775 (1,592)6,323 (1,538)0.356
OPG (pmol/L)2.80 (0.80)2.66 (0.60)0.365
sRANKL (pmol/L)303.5 (223.77)354.9 (259.4)0.379
RcIMT (mm)0.44 (0.06)0.46 (0.05)0.504
LcIMT (mm)0.46 (0.05)0.47 (0.05)0.916
CcIMT (mm)0.45 (0.05)0.47 (0.05)0.680

BMI: body mass index; eGFR: Estimated Glomerular Filtration Rate; Tchol: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density Lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; WBC: white blood cells; OPG: osteoprotegerin; sRANKL: serum receptor activator of nuclear factor-κB ligand; (R/L/C)cIMT: (right/left/combined) carotid intima-media thickness; SDS BMI: standardized BMI values: age and sex adjusted percentile.