International Journal of Endocrinology / 2013 / Article / Tab 2

Clinical Study

Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus

Table 2

Comparison of demographic, anthropometric, biochemical parameters and sonographic findings in children, and adolescents according to T1DM duration.

ParametersPatients with disease duration <7 years ( )
Mean ± SD
Patients with disease duration >/7 years ( )
Mean ± SD
P value

Age (years)11.53 (2.7)13.32 (3.3)0.076
BMI (kg/m2)20.34 (3.82)22.57 (3.26)0.044
HbA1c (%)7.83 (1.23)8.55 (2.13)0.133
Glucose (mg/dL)123.02 (68.86)203.29 (98.18)0.001
Diabetes duration (years)4.06 (1.54)9.39 (2.03)0.001
Urea (mg/dL)28.85 (7.72)32.01 (9.27)0.217
Creatinine (mg/dL)0.68 (0.14)0.79 (0.15)0.018
eGFR (mL/min)131.41 (24.33)133.93 (19.82)0.729
CRP (mg/dL)0.88 (1.43)0.71 (0.61)0.682
Tchol (mg/dL)160.66 (21.14)160.29 (32.30)0.961
TG (mg/dL)64.59 (30.46)93.71 (63.03)0.025
HDL-C (mg/dL)60.39 (10.48)55.43 (7.71)0.069
LDL-C (mg/dL)90.85 (19.80)91.07 (24.51)0.973
ApoA1 (mg/dL)154.43 (18.89)155.86 (17.24)0.804
ApoB (mg/dL)64.80 (11.10)66.86 (16.14)0.616
WBC (cells/μL)6,908 (1,619)6,385 (1,499)0.294
OPG (pmol/L)2.82 (0.87)2.74 (0.58)0.451
sRANKL (pmol/L)308.5 (237.7)288.6 (183.8)0.758
RcIMT (mm)0.42 (0.05)0.48 (0.04)0.094
LcIMT (mm)0.45 (0.04)0.50 (0.05)0.086
CcIMT (mm)0.44 (0.04)0.49 (0.04)0.072

BMI: body mass index; eGFR: Estimated Glomerular Filtration Rate; Tchol: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; WBC: white blood cells; OPG: osteoprotegerin; sRANKL: serum receptor activator of nuclear factor-κB ligand; (R/L/C)cIMT: (right/left/combined) carotid intima-media thickness.