Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus
Table 2
Comparison of demographic, anthropometric, biochemical parameters and sonographic findings in children, and adolescents according to T1DM duration.
Parameters
Patients with disease duration <7 years () Mean ± SD
Patients with disease duration >/7 years () Mean ± SD
P value
Age (years)
11.53 (2.7)
13.32 (3.3)
0.076
BMI (kg/m2)
20.34 (3.82)
22.57 (3.26)
0.044
HbA1c (%)
7.83 (1.23)
8.55 (2.13)
0.133
Glucose (mg/dL)
123.02 (68.86)
203.29 (98.18)
0.001
Diabetes duration (years)
4.06 (1.54)
9.39 (2.03)
0.001
Urea (mg/dL)
28.85 (7.72)
32.01 (9.27)
0.217
Creatinine (mg/dL)
0.68 (0.14)
0.79 (0.15)
0.018
eGFR (mL/min)
131.41 (24.33)
133.93 (19.82)
0.729
CRP (mg/dL)
0.88 (1.43)
0.71 (0.61)
0.682
Tchol (mg/dL)
160.66 (21.14)
160.29 (32.30)
0.961
TG (mg/dL)
64.59 (30.46)
93.71 (63.03)
0.025
HDL-C (mg/dL)
60.39 (10.48)
55.43 (7.71)
0.069
LDL-C (mg/dL)
90.85 (19.80)
91.07 (24.51)
0.973
ApoA1 (mg/dL)
154.43 (18.89)
155.86 (17.24)
0.804
ApoB (mg/dL)
64.80 (11.10)
66.86 (16.14)
0.616
WBC (cells/μL)
6,908 (1,619)
6,385 (1,499)
0.294
OPG (pmol/L)
2.82 (0.87)
2.74 (0.58)
0.451
sRANKL (pmol/L)
308.5 (237.7)
288.6 (183.8)
0.758
RcIMT (mm)
0.42 (0.05)
0.48 (0.04)
0.094
LcIMT (mm)
0.45 (0.04)
0.50 (0.05)
0.086
CcIMT (mm)
0.44 (0.04)
0.49 (0.04)
0.072
BMI: body mass index; eGFR: Estimated Glomerular Filtration Rate; Tchol: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; WBC: white blood cells; OPG: osteoprotegerin; sRANKL: serum receptor activator of nuclear factor-κB ligand; (R/L/C)cIMT: (right/left/combined) carotid intima-media thickness.
