International Journal of Endocrinology / 2013 / Article / Tab 3

Clinical Study

Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus

Table 3

Correlation between serum OPG, sRANKL, sonographic findings, and demographic, anthropometric, and biochemical parameters in children and adolescents with type 1 diabetes mellitus.

OPG
(pmol/L)
sRANKL
(pmol/L)
RcIMT
(mm)
LcIMT
(mm)
CcIMT
(mm)

Age (years)−0.271*−0.2030.2330.483**0.380*
BMI (kg/m2)−0.331**−0.1070.2940.489**0.418*
Diabetes duration (years)−0.1360.0400.2360.2420.176
HbA1c (%)0.0150.054−0.309−0.134−0.241
Glucose (mg/dL)0.1750.0430.2130.1120.178
Urea (mg/dL)0.0040.058−0.246−0.064−0.173
Creatinine (mg/dL)−0.200−0.1820.128−0.3550.255
eGFR (mL/min)−0.039−0.0330.1090.0900.186
CRP (mg/dL)0.077−0.007−0.265−0.352−0.331
Tchol (mg/dL)0.214−0.0120.003−0.197−0.099
TG (mg/dL)0.0480.0830.2470.2010.244
HDL-C (mg/dL)0.071−0.0450.0610.0060.038
LDL-C (mg/dL)0.197−0.025−0.079−0.267−0.182
ApoA1 (mg/dL)0.157−0.0960.0730.1430.115
ApoB (mg/dL)0.235−0.033−0.047−0.296−0.179
WBC (cells/μL)−0.0810.216−0.009−0.108−0.060
PLT (cells/μL)0.1170.1270.107−0.165−0.024
OPG (pmol/L)0.166−0.096−0.269−0.193
sRANKL (pmol/L)−0.221−0.290−0.231

P value < 0.05 and **P value < 0.01.
BMI: body mass index; eGFR: Estimated Glomerular Filtration Rate; Tchol: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; ApoA1: Apolipoprotein A1; ApoB: Apolipoprotein B; WBC: white blood cells; PLT: platelets; OPG: osteoprotegerin; sRANKL: serum receptor activator of nuclear factor-κB ligand; (R/L/C)cIMT: (right/left/combined) carotid intima-media thickness.