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International Journal of Endocrinology
Volume 2013 (2013), Article ID 126084, 5 pages
Clinical Study

Factors That Affect the False-Negative Outcomes of Fine-Needle Aspiration Biopsy in Thyroid Nodules

1Department of General Surgery, Istanbul Medical School, Istanbul University, 34493 Capa, Istanbul, Turkey
2General Surgery Clinic, Bagcilar Research and Training Hospital, Istanbul, Turkey
3Department of Pathology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
4Department of Radiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
5Department of Public Health, Istanbul Medical School, Istanbul University, Istanbul, Turkey

Received 3 December 2012; Revised 16 May 2013; Accepted 26 May 2013

Academic Editor: Stephen L. Atkin

Copyright © 2013 Orhan Agcaoglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The purpose of this study was to assess the factors that affect the false-negative outcomes of fine-needle aspiration biopsies (FNABs) in thyroid nodules. Methods. Thyroid nodules that underwent FNAB and surgery between August 2005 and January 2012 were analyzed. FNABs were taken from the suspicious nodules regardless of nodule size. Results. Nodules were analyzed in 2 different groups: Group 1 was the false-negatives ( ) and Group 2 was the remaining true-positives, true-negatives, and false-positives ( ). A cytopathologist attended in 559 (77%) of FNAB procedures. There was a positive correlation between the nodule size and false-negative rates, and the absence of an interpreting cytopathologist for the examination of the FNAB procedure was the most significant parameter with a 76-fold increased risk of false-negative results. Conclusion. The contribution of cytopathologists extends the time of the procedure, and this could be a difficult practice in centres with high patient turnovers. We currently request the contribution of a cytopathologist for selected patients whom should be followed up without surgery.