Vitamin D Status in Patients Operated for Primary Hyperparathyroidism: Comparison of Patients from Southern and Northern Europe

Table 1

Pre- and perioperative biochemical and clinical variables in patients operated on for primary hyperparathyroidism. Median, (IQR). Groups compared with Kruskal-wallis and chi square where appropriate.

Variable	All	Spanish cohort 𝑛=126	Swedish cohort 𝑛=128	P
Age (years)	65 (57–73)	64 (57–72)	66 (58–74)	0.33
p-Ca (mmol/L)	2.74 (2.65–2.85)	2.74 (2.65–2.85)	2.74 (2.66–2.84)	0.73
PTH (pmol/L)	12 (9.3–16.2)	13.5 (10.5–20.4)	11.0 (8.4–14.0)	<0.001
25-OH-D (nmol/L)	44 (26–64)	40 (25–58)	51 (28–66)	0.01
1,25-OH-D (pmol/L)	55 (98–162)	142 (99–198)	56 (28–66)	<0.001
Phosphate (mmol/L)	0.85 (0.77–0.96)	0.90 (0.80–1.0)	0.82 (0.72–0.90)	<0.001
ALP (unit)	2.6 (1.6–3.8)	3.0 (1.7–4.3)	2.3 (1.5–3.4)	0.002
GFR (mL/min)	75 (63–89)	70 (58–85)	76 (65–93)	0.01
Creatinine (umol/L)	71 (62–81)	80 (71–88)	65 (56–73)	<0.001
Urinary calcium (unit)	5.9 (3.6–9)	7.3 (3.9–10.0)	4.1 (2.8–5.9)	<0.001
Fracture (yes/no)	48/195	19/107	29/99	0.002
Vitamin D deficiency (yes/no)	130/96	80/42	50/54	0.007
Adenoma weight (mg)	546 (300–1200)	620 (290–1400)	500 (320–1030)	<0.001