Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index

Table 2

Correlation between acylated ghrelin, desacylated ghrelin, preptin, nesfatin-1, and leptin levels and BMI in study groups.

Peptides	Group I		Group II		Group III		Group VI		Group V
	(𝑛: 31)		(𝑛: 28)		(𝑛: 31)		(𝑛: 30)		(𝑛: 30)
	(16 females, 15 males)		(14 females, 14 males)		(16 females, 15 males)		(15 females, 15 males)		(15 females, 15 males)
	𝑟	𝑃	𝑟	𝑃	𝑟	𝑃	𝑟	𝑃	𝑟	𝑃
Acylated ghrelin	−0.563	0.001	−0.071	0.721	0.147	0.438	−0.213	0.258	0.031	0.870
Desacylated ghrelin	−0.174	0.349	0.032	0.870	0.123	0.519	0.099	0.603	−0.125	0.509
Preptin	0.194	0.296	0.190	0.332	−0.144	0.447	−0.400	0.029	0.164	0.385
Nesfatin-1	0.111	0.551	−0.370	0.853	0.180	0.342	−0.760	0.688	−0.149	0.433
Leptin	−0.001	0.995	0.109	0.582	0.220	0.243	−0.111	0.561	−0.208	0.270

In brief, the increase in serum preptin and leptin levels is in a positive correlation with BMI. However, a fluctuation was observed in nesfatin-1 levels in such a way that nesfatin-1 levels increased in individuals with a BMI of up to 30 kg/m² but decreased in obese (Group IV) and morbidly obese (Group V) individuals. Desacylated ghrelin dropped in all groups with increasing BMI that is, desacylated ghrelin is inversely correlated with BMI, while acylated ghrelin fluctuated.