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International Journal of Endocrinology
Volume 2013 (2013), Article ID 240971, 6 pages
http://dx.doi.org/10.1155/2013/240971
Clinical Study

Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2

1Department of Endocrinology and Metabolism, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
2Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China

Received 22 November 2012; Revised 17 March 2013; Accepted 19 March 2013

Academic Editor: Stephen L. Atkin

Copyright © 2013 Chandrama Shrestha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. We investigated the changes in adipokines and sICAM-1 in Chinese subjects with low BMI and T2DM after LRYGB and explored their relationship with postsurgical insulin sensitivity. Methods. Plasma levels of adiponectin, sICAM-1, fasting glucose, glycated hemoglobin, and fasting insulin and serum levels of visfatin were measured before and at three months after LRYGB in 33 T2DM patients with BMI of 22–30 kg·m−2. Results. Significant reductions in anthropometric measurements and indicators of glucose and lipid metabolism and moderate reductions in insulin resistance and fasting insulin were observed at three months after LRYGB. Postoperative adiponectin level ( ) was increased compared to the preoperative level, whereas visfatin ( ) and sICAM-1 ( ) were lower than that before surgery. Serum adiponectin negatively correlated with HOMA-IR and FIns both preoperatively and at three months after surgery, and visfatin positively correlated with HOMA-IR and FIns both preoperatively and postoperatively. Conclusion. Changes in adipokines were related to an improvement in postsurgical insulin sensitivity, which was predicted by weight loss after LRYGB even in low BMI patients with T2DM.