Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas
Figure 1
(a) Pictures that show the hydrogel part of the IvS-1 continuous blood glucose monitor prototype at increasing magnification; (b) a classic example of oscillating blood glucose levels with a periodicity of approximately 10 minutes and an amplitude of approximately 0.05 mmol/L (from animal 2, which was only mildly affected by the streptozotocin pretreatment; measurements from 60 to 120 minutes in the actual experiment after IvS-1 stabilization but before the first insulin bolus; artifact seen at 103 minutes).
