Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses: Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas

Table 1

The seven outcome variables from the four animals; BGL₀: the blood glucose level at the time of the first insulin bolus; BGL_low: the lowest blood glucose level recording during the experiment; 𝑇_est: time to establish glycemic control from the first insulin bolus until the blood glucose level went below 6.0 mmol/L; RD: the rate of blood glucose level decrease during 𝑇_est; 𝑇_ctrl: time with glycemic control from blood glucose level went below 6.0 mmol/L until end of experiment; 𝑇_low: total time with blood glucose levels below 4.5 mmol/L during 𝑇_ctrl; 𝑇_range: percentage time with BGL in the correct range between 4.5 and 6.0 mmol/L during 𝑇_ctrl.

Animal	BGL0 (mmol/L)	BGLlow (mmol/L)	𝑇est (min)	RD ((mmol/L)/min)	𝑇ctrl (min)	𝑇low (min)	𝑇range (%)
1	7.53	3.81	68	0.025	186	51	73
2	7.46	4.14	21	0.073	146	20	86
3	9.33	4.44	63	0.064	238	3	99
4	14.06	4.04	121	0.077	128	22	83