Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2013, Article ID 309191, 5 pages
http://dx.doi.org/10.1155/2013/309191
Review Article

Exercise for Hepatic Fat Accumulation in Type 2 Diabetic Subjects

Unit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani 1, 37126 Verona, Italy

Received 1 July 2013; Accepted 26 July 2013

Academic Editor: Ilias Migdalis

Copyright © 2013 Elisabetta Bacchi and Paolo Moghetti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. J. Nolan, P. Damm, and M. Prentki, “Type 2 diabetes across generations: from pathophysiology to prevention and management,” The Lancet, vol. 378, no. 9786, pp. 169–181, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. N. F. Schwenzer, F. Springer, C. Schraml, N. Stefan, J. Machann, and F. Schick, “Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance,” Journal of Hepatology, vol. 51, no. 3, pp. 433–445, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Targher, C. P. Day, and E. Bonora, “Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease,” The New England Journal of Medicine, vol. 363, no. 14, pp. 1341–1350, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. S. R. Mehta, “Advances in the treatment of nonalcoholic fatty liver disease,” Therapeutic Advances in Endocrinology and Metabolism, vol. 1, no. 3, pp. 101–115, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Musso, M. Cassader, F. Rosina, and R. Gambino, “Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials,” Diabetologia, vol. 55, no. 4, pp. 885–904, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Mouzaki and J. P. Allard, “The role of nutrients in the development, progression, and treatment of nonalcoholic fatty liver disease,” Journal of Clinical Gastroenterology, vol. 46, no. 6, pp. 457–467, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. R. Colberg, R. J. Sigal, B. Fernhall et al., “Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement,” Diabetes Care, vol. 33, no. 12, pp. e147–e167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Bacchi, C. Negri, M. E. Zanolin et al., “Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study),” Diabetes Care, vol. 35, no. 4, pp. 676–682, 2012. View at Google Scholar
  9. R. J. Sigal, G. P. Kenny, N. G. Boulé et al., “Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial,” Annals of Internal Medicine, vol. 147, no. 6, pp. 357–369, 2007. View at Google Scholar · View at Scopus
  10. T. S. Church, S. N. Blair, S. Cocreham et al., “Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial,” The Journal of the American Medical Association, vol. 304, no. 20, pp. 2253–2262, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Tamura, Y. Tanaka, F. Sato et al., “Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 6, pp. 3191–3196, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Bonekamp, B. B. Barone, J. Clark, and K. J. Stewart, “The effect of an exercise training intervention on hepatic steatosis,” Hepatology, vol. 48, 2008, abstract 806A. View at Google Scholar
  13. M. Lazo, S. F. Solga, A. Horska et al., “Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes,” Diabetes Care, vol. 33, no. 10, pp. 2156–2163, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. J. B. Albu, L. K. Heilbronn, D. E. Kelley et al., “Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes,” Diabetes, vol. 59, no. 3, pp. 627–633, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Bozzetto, A. Prinster, G. Annuzzi et al., “Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients,” Diabetes Care, vol. 35, no. 7, pp. 1429–1435, 2012. View at Google Scholar
  16. E. Bacchi, C. Negri, G. Targher et al., “Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with NAFLD (The RAED2 randomized trial),” Hepatology, 2013. View at Publisher · View at Google Scholar
  17. N. A. Johnson, T. Sachinwalla, D. W. Walton et al., “Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss,” Hepatology, vol. 50, no. 4, pp. 1105–1112, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Hallsworth, G. Fattakhova, K. G. Hollingsworth et al., “Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss,” Gut, vol. 60, no. 9, pp. 1278–1283, 2011. View at Publisher · View at Google Scholar · View at Scopus