Research Article
The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model
Table 1
Clinical and laboratory findings.
| ā | Control, = 10 | Genta, = 10 | Genta + Vit D, = 10 |
| SBP (mmHg) | 120 6 | 125 10 | 112 13a | DBP (mmHg) | 68 4 | 75 7 | 74 8 | Urine volume (cc) | 3 0.5 | 2.4 0.4 | 3.4 0.5a | Urea (mg/dL) | 91 6 | 137 6a | 149 5a | Creatinine (mg/dL) | 0.74 0.03 | 1.1 0.1a | 1.6 0.3a | NGAL (ng/mL) | 49.5 7 | 390 143a | 247 112 | GSH (nmol/mL) | 0.4 0.13 | 0.3 0.04 | 0.6 0.1a | GGT (U/L) | 1.3 0.35 | 38 37 | 59 19a | KIM-1 (ng/mL) | 0.64 0.05 | 4.7 0.6a | 6 0.5a | TD | 0.9 0.1 | 2 0a | 2.3 0.2a | TN | 0 | 1.3 0.2a | 1.2 0.2a | TIN | 0.4 0.2 | 1.4 0.2a | 2 0.1ab | THS | 0.75 0.15 | 3.4 0.4a | 6.3 0.7ab |
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SBP: systolic blood pressure; DBP: diastolic blood pressure; NGAL: neutrophil gelatinase-associated lipocalin; GSH: glutathione; KIM: kidney injury molecule; TD: tubular degeneration; TN: tubular necrosis; TIN: tubulointerstitial nephritis; THS: total histological score; < 0.05, aGroup versus Control, bGroup versus Genta.
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