Hepatic Steatosis and Thyroid Function Tests in Overweight and Obese Children
Table 1
Baseline characteristics of 402 overweight/obese children according to serum TSH.
Serum TSH
value
≤4 mIU/L ()
>4 mIU/L ()
TSH, mIU/L
2.42 (2.33–2.52)
4.74 (4.52–4.95)
<0.0001
Age, years
10.7 (10.3–11.1)
10.9 (10.0–11.2)
0.46
Male gender, (%)
175 (55.7)
55 (62.5)
0.35
Prepubertal, (%)
159 (50.6)
58 (65.9)
0.56
Weight, Kg
61 (59–63)
60 (55–65)
0.70
Height, cm
149 (147–152)
149 (144–153)
0.80
BMI, Kg/m2
26.3 (25.7–26.8)
26.3 (25.2–27.3)
0.75
BMI-SDS
2.0 (1.94–2.2)
2.0 (1.9–2.2)
0.80
Waist circumference, cm
87 (84–90)
89 (87–90)
0.26
Systolic blood pressure, mmHg
109 (107–110)
110 (107–112)
0.88
Diastolic blood pressure, mmHg
69 (68–70)
70 (67–72)
0.82
Triglycerides, mg/dL
99 (90–108)
119 (103–135)
<0.01
Total cholesterol, mg/dL
160 (156–165)
176 (166–186)
<0.01
HDL-C, mg/dL
47 (46–49)
45 (43–48)
0.30
Fasting glucose, mmol/L
4.71 (4.64–4.78)
4.67 (4.58–4.75)
0.48
Insulin, mU/L
16.0 (15.0–18.0)
19.3 (16.5–22.0)
<0.05
HOMA-IR values
3.62 (3.22–4.0)
4.0 (3.4–4.6)
<0.05
ALT, IU/L
31 (28–35)
52 (36–68)
<0.01
GGT, IU/L
17 (16–19)
22 (18–26)
<0.01
FT3, pg/mL
4.26 (4.18–4.35)
4.35 (4.26–4.42)
0.14
FT4, ng/dL
1.18 (1.15–1.22)
1.18 (1.12–1.22)
0.76
Data are expressed as (%), mean or geometric mean (95% confidence intervals). TSH: thyroid-stimulating hormone; BMI: body mass index; BMI-SDS: BMI-SD score; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; ALT: alanine aminotransferase; GGT: gamma-glutamyl transferase; FT3: free triiodothyronine; FT4: free thyroxine.
