Hepatic Steatosis and Thyroid Function Tests in Overweight and Obese Children
Table 3
Adjusted odds ratios (and 95% CIs) of hepatic steatosis, hepatic steatosis with elevated ALT, metabolic syndrome, and its components among 402 overweight/obese children.
Serum TSH
value
≤4 mIU/L ()
>4 mIU/L ()
Hepatic steatosis
Adjusted OR (95% CI)+,*
1.00 (referent)
2.10 (1.22–3.60)
<0.01
Hepatic steatosis with elevated ALT
Adjusted OR (95% CI)+,*
1.00 (referent)
2.42 (1.29–4.51)
<0.01
Central obesity
Adjusted OR (95% CI)+
1.00 (referent)
1.32 (0.57–3.01)
0.52
Elevated blood pressure
Adjusted OR (95% CI)+,*
1.00 (referent)
1.31 (0.41–4.17)
0.58
Hypertriglyceridemia
Adjusted OR (95% CI)+,*
1.00 (referent)
2.58 (1.39–4.78)
<0.01
Low HDL-C
Adjusted OR (95% CI)+,*
1.00 (referent)
1.97 (0.98–3.98)
0.063
Elevated total cholesterol
Adjusted OR (95% CI)+,*
1.00 (referent)
2.23 (1.30–3.84)
<0.01
Glucose 5.6 mmol/L
Adjusted OR (95% CI)+,*
1.00 (referent)
0
Insulin resistance
Adjusted OR (95% CI)+,*
1.00 (referent)
2.62 (1.45–4.74)
<0.01
Metabolic syndrome
Adjusted OR (95% CI)+,*
1.00 (referent)
2.55 (1.13–5.76)
<0.05
Age, gender, pubertal status, and BMI-SDS as well as FT3 and FT4 were included in the model; *similar results were obtained when adjusting for WC (instead of BMI-SDS). TSH: thyroid-stimulating hormone; OR: odds ratio; CI: confidence interval; ALT: alanine aminotransferase; HDL-C: high-density lipoprotein cholesterol; BMI-SDS: body mass index-SD score; FT3: free triiodothyronine; FT4: free thyroxine; WC: waist circumference.