Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

Table 1

Mechanisms of PVAT dysfunction.

(i) Increase in adipocyte size and PVAT amount
(ii) Hypoxia
(iii) Aging
(iv) Leptin/adiponectin dysregulation
(v) Loss of anticontractile properties
(vi) Loss of eNOS and NO
(vii) Increase in oxidative stress
(viii) Increase in inflammatory response