Research Article

Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies

Table 7

Percent difference in the production of nine lipid signaling molecules in midbrain, striatum, and hippocampus. (a–c) Percent change of N-arachidonoyl ethanolamine (anandamide; AEA); N-arachidonoyl glycine (NAGly); N-palmitoyl ethanolamine (PEA); N-stearoyl ethanolamine (SEA); N-oleoyl ethanolamine (OEA); N-docosahexaenoyl ethanolamine (DHEA); 2-arachidonoyl glycerol (2-AG); prostaglandin E2 (PGE2); and prostaglandin F2 alpha (PGF2α). Comparisons are from (a) home cage, (b) chamber exposed, and (c) standard mated. Only percent differences of those means that were significantly different are shown. Averages and analysis of significant differences are shown in Tables 4, 5, and 6.
(a)

Chamber exposed compared to home cage control
HippocampusMidbrainStriatumBrainstem

AEA↑(50%)
NAGly↑(83%)
PEA↑(109%)↑(64%)
SEA↑(100%)
OEA↑(52%)↑(56%)
DHEA↑(62%)↑(42%)
2-AG(25%)↑(21%)(33%)
PGE2↑(119%)↑(62%)
PGF2α

(b)

Paced mating compared to chamber exposed
HippocampusMidbrainStriatumBrainstem

AEA(49%)(44%)(45%)(52%)
NAGly(57%)(40%)(35%)
PEA(64%)(39%)(47%)(41%)
SEA(50%)(25%)(22%)
OEA(53%)(42%)(45%)(39%)
DHEA(50%)(32%)(45%)(28%)
2-AG(24%)
PGE2(63%)
PGF2α(49%)

(c)

Paced mating compared to standard mating
HippocampusMidbrainStriatumBrainstem

AEA(33%)(48%)(40%)
NAGly(17%)↑(23%)
PEA(44%)(34%)(40%)
SEA(29%)(40%)
OEA(40%)(38%)(41%)
DHEA(32%)(31%)(40%)
2-AG(18%)(25%)
PGE2(59%)
PGF2α(33%)(48%)(40%)