Clinical Characteristics of Endogenous Cushing’s Syndrome at a Medical Center in Southern Taiwan

Table 1

Patient distribution and demographic data for the 84 patients with various causes of Cushing's syndrome.

Causes of Cushing's syndrome	Number of patients (%)	Sex (F : M)	Mean age (yr) at operation (range)
ACTH-independent Cushing's syndrome	63 (75%)	46 : 17	37.5 ± 14.2 (0.7–67.7)
(1) Adrenocortical adenoma	49 (58.3%)	40 : 9	35.3 ± 13.1 (0.7–67.7)
Unilateral	48 (57.1%)	39 : 9
Bilateral	1 (1.2%)	1 : 0
(2) Adrenocortical carcinoma	7 (8.3%)	5 : 2	44.8 ± 21.8 (1.3–66)
Unilateral	6 (7.1%)	5 : 1
Bilateral	1 (1.2%)	0 : 1
(3) PPNAD*	4 (4.8%)	1 : 3	37.8 ± 8.2 (25–45.8)
(4) AIMAH**	3 (3.6%)	0 : 3	54.9 ± 9.8 (43.8–62.6)
ACTH-dependent Cushing's syndrome	21 (25%)	16 : 5	40.9 ± 16.1 (14–67)
(1) Cushing's disease	18 (21.4%)	15 : 3	40.3 ± 16.3 (14–67)
(2) Ectopic ACTH syndrome	3 (3.6%)	1 : 2	45.1 ± 17.5 (25–57)

∗PPNAD: primary pigmented nodular adrenocortical disease.
∗∗AIMAH: ACTH-independent bilateral macronodular adrenocortical hyperplasia.