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International Journal of Endocrinology
Volume 2013, Article ID 715025, 9 pages
Research Article

Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort

1Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA
2Wade Outcomes Research and Consulting, 358 South 700 East, Suite B432, Salt Lake City, UT 84102, USA
3Q.D. Research, Inc., 8789 Auburn Folsom Road, Suite C501, Granite Bay, CA 95746, USA
4Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, 10 S. Pine Street, MSTF 8-34, Baltimore, MD 21201, USA

Received 21 December 2012; Revised 21 February 2013; Accepted 7 March 2013

Academic Editor: Cory Xian

Copyright © 2013 Nicole Yurgin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Subject- and physician-reported data from 4,429 postmenopausal women receiving osteoporosis treatment in the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US) were used to assess the prevalence of risk factors (RFs) and on-study fracture. RFs assessed at study entry were age >70 years; fracture since age 50; minimum T-score (hip/spine) ≤−2.5 at diagnosis; body mass index <18.5 kg/m2; rheumatoid arthritis; parental history of hip fracture; current smoking; and recent oral glucocorticoid use. Data were collected with semiannual self-administered questionnaires. Results were stratified by physician-reported osteoporosis/osteopenia diagnosis. Low T-score and age >70 years were the most common RFs in the osteoporosis group, and age >70 years and prior fracture were the most common risk factors in the osteopenia group. Multiple RFs were more common than a single RF in osteoporotic women (54.2% versus 34.6%; ) but not osteopenic women (13.8% versus 33.6%; ). Women with multiple RFs had more on-study osteoporosis-related fractures than women with a single RF (osteoporosis group: 9.9% versus 6.2%; ; osteopenia group: 11.2% versus 4.7%; ). In postmenopausal women receiving osteoporosis treatment, multiple RFs increased fracture risk. RFs, in addition to bone mineral density, can help identify candidates for osteoporosis treatment.