Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort
Table 2
Subject-reported on-study osteoporosis-related fracture stratified by number of risk factors.
Subjects with 0 risk factors
Subjects with 1 risk factor
Subjects with ≥2 risk factors
(%)
(%)
(%)
Osteoporotic subjects
214
663
1,039
Any osteoporosis-related fracture
9 (4.2)
41 (6.2)
103 (9.9)
Hip fracture
0 (0)
4 (0.6)
31 (3.0)
Spine fracture
2 (0.9)
7 (1.1)
26 (2.5)
Nonhip/nonspine fracture
7 (3.3)
33 (5.0)
64 (6.2)
Multiple osteoporosis-related fractures
1 (0.5)
10 (1.5)
35 (3.4)
Osteopenic subjects
1,322
843
348
Any osteoporosis-related fracture
59 (4.5)
40 (4.8)
39 (11.2)
Hip fracture
8 (0.6)
6 (0.7)
8 (2.3)
Spine fracture
11 (0.8)
7 (0.8)
11 (3.2)
Nonhip/nonspine fracture
47 (3.6)
28 (3.3)
24 (6.9)
Multiple osteoporosis-related fractures
14 (1.1)
10 (1.2)
13 (3.7)
Risk factors: age > 70 years, history of fracture since age 50, minimum hip or spine T-score ≤ −2.5 at diagnosis, body mass index < 18.5 kg/m2, rheumatoid arthritis, parental history of hip fracture, current cigarette smoking, and glucocorticoid use in 6 months prior to study entry.
