Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness
Table 1
Clinical and biochemical characteristics of participants with GCK-MODY and control individuals.
Controls
GCK-MODY
P value
n = 24
n = 27
Gender
Female
13 (54.2%)
12 (44.4%)
0.58
Male
11 (45.8%)
15 (55.6%)
Smoking
Nonsmoker
20 (83.3%)
22 (81.5%)
1
Smoker
4 (16.7%)
5 (18.5%)
Age [yr]
53 (12.2)
49.8 (12.1)
0.35
Weight [kg]
81.7 (14)
77.2 (12.9)
0.23
Height [cm]
172 (7.43)
170 (7.34)
0.35
BMI [kg/m2]
27.7 (4.32)
26.8 (4.04)
0.43
Waist circumference [cm]
96.8 (13.6)
92.1 (12.3)
0.20
Hip circumference [cm]
108 (7.97)
104 (9.88)
0.081
Waist-to-hip ratio
0.892 (0.083)
0.881 (0.121)
0.73
Systolic blood pressure [mmHg]
124 (12.8)
122 (20.8)
0.8
Diastolic blood pressure [mmHg]
75.6 (9.7)
72.6 (12.5)
0.34
Glycemia [mmol/L], [mg/dl]
5.26 (0.33), 95.4
7.58 (1.17), 136.4
<0.001
HbA1c [%]
5.74 (0.381)
6.92 (0.957)
<0.001
HbA1c [mmol/mol]
39 (3)
52 (10)
<0.001
C-peptide [pmol/L]
871 (301)
853 (545)
0.89
Total cholesterol [mmol/L]
5.42 (0.866)
5.15 (0.856)
0.26
HDL cholesterol [mmol/L]
1.51 (0.368)
1.52 (0.366)
0.94
LDL cholesterol [mmol/L]
3.16 (0.66)
2.85 (0.757)
0.13
Triglycerides [mmol/L]
1.54 (0.858)
1.58 (1.33)
0.9
Creatinine [mmol/L]
70.5 (19.1)
73.6 (22.1)
0.59
GMT [kat/L]
0.468 (0.307)
0.647 (0.785)
0.28
Microalbuminuria [μg/mg creatinine]
6.58 (10.1)
24.8 (61)
0.15
Albumin/creatinine ratio
0.818 (1.56)
5.11 (14.6)
0.17
Intima-media thickness [mm]
0.692 (0.189)
0.707 (0.215)
0.78
Numbers and percentages are shown for categorical variables; means and standard deviations are shown for numerical variables. P values compare the unadjusted means/percentages between the two groups. The bold font refers to statistically significantP values; P values less than 0.05 were considered as statistically significant.
