Prognosis of Multifocal Papillary Thyroid Carcinoma

Table 1

Clinical features of multifocal papillary thyroid carcinoma (PTC) in microcarcinoma (PTMC) and non-PTMC groups.

	PTMC (𝑛=108)	Non-PTMC^#(𝑛=375)	Multifocal PTC (𝑛=483)	𝑃 value
Age (yr)	46.0±11.9	45.5±14.3	45.6±13.8	0.7289
Female gender (%)	85 (78.7)	299 (79.7)	384 (79.5)	0.8153
Total or complete thyroidectomy (%)	91 (84.3)	363 (96.8)	454 (94.0%)	0.0001
Tumor size (cm)	0.7±0.03	2.6±0.1	2.2±0.1	0.0001
TNM stage I (%)	92 (85.2)	213 (56.8)	305 (63.1)	0.0001
Postoperative Tg* (ng/dL)	161±86	139±32	143±30.7	0.7663
^131I dose accumulative dose (mCi)	150±22.1	152±11.2	151±10.0	0.9583
Postoperative progression	14 (13.1)	84 (22.4)	98 (20.3)	0.0347
Follow-up period (yr)	5.3±0.5	6.4±0.3	6.1±0.2	0.0503
Thyroid cancer mortality (%)	5 (4.6)	13 (3.5)	18 (3.7)	0.5679
Total mortality (%)	8 (7.4)	26 (6.9)	34 (7.0)	0.8652

Non-PTMC^#: largest diameter of tumor over 1 cm; Tg*: serum thyroglobulin levels 4 to 6 weeks after thyroidectomy.