Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2013, Article ID 854623, 7 pages
http://dx.doi.org/10.1155/2013/854623
Research Article

Orexin A Affects INS-1 Rat Insulinoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway

1Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
2Department of Orthopedic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China

Received 17 August 2013; Revised 10 October 2013; Accepted 10 November 2013

Academic Editor: Stuart Tobet

Copyright © 2013 Li Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [11 citations]

The following is the list of published articles that have cited the current article.

  • David Alexandre, Coralie Hautot, Marwa Mehio, Lydie Jeandel, Maïté Courel, Thierry Voisin, Alain Couvineau, Françoise Gobet, Jérôme Leprince, Christian Pfister, Youssef Anouar, and Nicolas Chartrel, “The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis,” European Journal of Cancer, 2014. View at Publisher · View at Google Scholar
  • Salvatore Valiante, Giovanna Liguori, Simona Tafuri, Luigi Michele Pavone, Roberto Campese, Roberto Monaco, Giuseppina Iachetta, Loredana Assisi, Nicola Mirabella, Maurizio Forte, Anna Costagliola, and Alfredo Vittoria, “Expression and potential role of the peptide orexin-A in prostate cancer,” Biochemical and Biophysical Research Communications, 2015. View at Publisher · View at Google Scholar
  • Xiaocen Chang, Yuyan Zhao, and Lei Guo, “Effect of Orexin-A on Cortisol Secretion in H295R Cells via p70S6K/4EBP1 Signaling Pathway,” International Journal of Endocrinology, vol. 2015, pp. 1–6, 2015. View at Publisher · View at Google Scholar
  • Marek Skrzypski, Iwona Hertig, Paweł A Kołodziejski, Mathias Z Strowski, Krzysztof W Nowak, Tatiana Wojciechowicz, Dawid Szczepankiewicz, and Maria Billert, “Original Research: Orexins A and B stimulate proliferation and differentiation of porcine preadipocytes,” Experimental Biology and Medicine, vol. 241, no. 16, pp. 1786–1795, 2016. View at Publisher · View at Google Scholar
  • Yuanyuan Liu, Yuyan Zhao, and Lei Guo, “Effects of orexin A on glucose metabolism in human hepatocellular carcinoma in vitro via PI3K/Akt/mTOR-dependent and -independent mechanism,” Molecular and Cellular Endocrinology, vol. 420, pp. 208–216, 2016. View at Publisher · View at Google Scholar
  • Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, and Mehdi Abbasnejad, “Orexin-A Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity: Involvement of PKC and PI3K Signaling Pathways,” Rejuvenation Research, 2017. View at Publisher · View at Google Scholar
  • Haiyang Zhang, Bin Liang, Tao Li, Yi Zhou, Deya Shang, and Zhongjun Du, “ Orexin A Suppresses Oxidized LDL Induced Endothelial Cell Inflammation via MAPK p38 and NF-κB Signaling Pathway ,” IUBMB Life, 2018. View at Publisher · View at Google Scholar
  • Xuesong Han, Jicheng Zhou, and Wei Peng, “Orexins Facilitates Osteogenic Differentiation of MC3T3-E1 Cells,” IUBMB Life, vol. 70, no. 7, pp. 633–641, 2018. View at Publisher · View at Google Scholar
  • Chun-Mei Wang, Chun-Qing Yang, Bao-Hua Cheng, Jing Chen, and Bo Bai, “ Orexin-A protects SH-SY5Y cells against H 2 O 2 -induced oxidative damage via the PI3K/MEK 1/2 /ERK 1/2 signaling pathway ,” International Journal of Immunopathology and Pharmacology, vol. 32, pp. 205873841878573, 2018. View at Publisher · View at Google Scholar
  • Chunmei Wang, Qinqin Wang, Bingyuan Ji, Yanyou Pan, Chao Xu, Baohua Cheng, Bo Bai, and Jing Chen, “The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases,” Frontiers in Molecular Neuroscience, vol. 11, 2018. View at Publisher · View at Google Scholar
  • M Skrzypski, M Billert, K W Nowak, and M Z Strowski, “The role of orexin in controlling the activity of the adipo-pancreatic axis,” Journal of Endocrinology, vol. 238, no. 2, pp. R95–R108, 2018. View at Publisher · View at Google Scholar