Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2013 (2013), Article ID 854623, 7 pages
http://dx.doi.org/10.1155/2013/854623
Research Article

Orexin A Affects INS-1 Rat Insulinoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway

1Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
2Department of Orthopedic Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China

Received 17 August 2013; Revised 10 October 2013; Accepted 10 November 2013

Academic Editor: Stuart Tobet

Copyright © 2013 Li Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Sakurai, A. Amemiya, M. Ishii et al., “Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior,” Cell, vol. 92, no. 4, pp. 573–585, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. L. De Lecea, T. S. Kilduff, C. Peyron et al., “The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 1, pp. 322–327, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Karteris and H. S. Randeva, “Orexin receptors and G-protein coupling: evidence for another “promiscuous” seven transmembrane domain receptor,” Journal of Pharmacological Sciences, vol. 93, no. 1, pp. 126–128, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. A. L. Kirchgessner, “Orexins in the brain-gut axis,” Endocrine Reviews, vol. 23, no. 1, pp. 1–15, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. M. López, R. Señaris, R. Gallego et al., “Orexin receptors are expressed in the adrenal medulla of the rat,” Endocrinology, vol. 140, no. 12, pp. 5991–5994, 1999. View at Google Scholar · View at Scopus
  6. M. Nakabayashi, T. Suzuki, K. Takahashi et al., “Orexin-A expression in human peripheral tissues,” Molecular and Cellular Endocrinology, vol. 205, no. 1-2, pp. 43–50, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. O. Jöhren, S. J. Neidert, M. Kummer, A. Dendorfer, and P. Dominiak, “Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats,” Endocrinology, vol. 142, no. 8, pp. 3324–3331, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Ammoun, T. Holmqvist, R. Shariatmadari et al., “Distinct recognition of OX1 and OX2 receptors by orexin peptides,” The Journal of Pharmacology and Experimental Therapeutics, vol. 305, no. 2, pp. 507–514, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. C. M. Kotz, “Integration of feeding and spontaneous physical activity: role for orexin,” Physiology and Behavior, vol. 88, no. 3, pp. 294–301, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. J. P. Nixon, C. M. Kotz, C. M. Novak, C. J. Billington, and J. A. Teske, “Neuropeptides controlling energy balance: orexins and neuromedins,” Handbook of Experimental Pharmacology, vol. 209, pp. 77–109, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Ouedraogo, E. Näslund, and A. L. Kirchgessner, “Glucose regulates the release of orexin-A from the endocrine pancreas,” Diabetes, vol. 52, no. 1, pp. 111–117, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Göncz, M. Z. Strowski, C. Grötzinger et al., “Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway,” Endocrinology, vol. 149, no. 4, pp. 1618–1626, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. K. W. Nowak, M. Z. Strowski, M. M. Switonska et al., “Evidence that orexins A and B stimulate insulin secretion from rat pancreatic islets via both receptor subtypes,” International Journal of Molecular Medicine, vol. 15, no. 6, pp. 969–972, 2005. View at Google Scholar · View at Scopus
  14. K. W. Nowak, P. Maćkowiak, M. M. Switońska, M. Fabiś, and L. K. Malendowicz, “Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies,” Life Science, vol. 66, no. 5, pp. 449–454, 1999. View at Publisher · View at Google Scholar
  15. P. Rouet-Benzineb, C. Rouyer-Fessard, A. Jarry et al., “Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis,” The Journal of Biological Chemistry, vol. 279, no. 44, pp. 45875–45886, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Voisin, A. E. Firar, V. Avondo, and M. Laburthe, “Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor,” Endocrinology, vol. 147, no. 10, pp. 4977–4984, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Sokołowska, A. Urbańska, M. Namiecińska, K. Biegańska, and J. B. Zawilska, “Orexins promote survival of rat cortical neurons. .,” Neuroscience Letters, vol. 506, no. 2, pp. 303–306, 2012. View at Publisher · View at Google Scholar
  18. M. Skrzypski, P. Kaczmarek, T. T. Le et al., “Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes,” FEBS Letters, vol. 586, no. 23, pp. 4157–4164, 2012. View at Publisher · View at Google Scholar
  19. D. P. Brazil and B. A. Hemmings, “Ten years of protein kinase B signalling: a hard Akt to follow,” Trends in Biochemical Sciences, vol. 26, no. 11, pp. 657–664, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. T. O. Chan, S. E. Rittenhouse, and P. N. Tsichlis, “AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation,” Annual Review of Biochemistry, vol. 68, pp. 965–1014, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. J. L. Beith, E. U. Alejandro, and J. D. Johnson, “Insulin stimulates primary β-cell proliferation via Raf-1 kinase,” Endocrinology, vol. 149, no. 5, pp. 2251–2260, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. A. L. Kirchgessner and M.-T. Liu, “Orexin synthesis and response in the gut,” Neuron, vol. 24, no. 4, pp. 941–951, 1999. View at Google Scholar · View at Scopus
  23. L. M. Dickson and C. J. Rhodes, “Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?” American Journal of Physiology: Endocrinology and Metabolism, vol. 287, no. 2, pp. E192–E198, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Liadis, K. Murakami, M. Eweida et al., “Caspase-3-dependent β-cell apoptosis in the initiation of autoimmune diabetes mellitus,” Molecular and Cellular Biology, vol. 25, no. 9, pp. 3620–3629, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Zwirska-Korczala, M. Adamczyk-Sowa, P. Sowa et al., “Role of leptin, ghrelin, angiotensin II and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism,” Journal of Physiology and Pharmacology, vol. 58, supplement 1, pp. 53–64, 2007. View at Google Scholar · View at Scopus
  26. R. Spinazzi, A. Ziolkowska, G. Neri et al., “Orexins modulate the growth of cultured rat adrenocortical cells, acting through type 1 and type 2 receptors coupled to the MAPK p42/p44- and p38-dependent cascades,” International Journal of Molecular Medicine, vol. 15, no. 5, pp. 847–852, 2005. View at Google Scholar · View at Scopus
  27. A. El Firar, T. Voisin, C. Rouyer-Fessard, M. A. Ostuni, A. Couvineau, and M. Laburthe, “Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis,” The FASEB Journal, vol. 23, no. 12, pp. 4069–4080, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. R. S. Garofalo, S. J. Orena, K. Rafidi et al., “Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ,” Journal of Clinical Investigation, vol. 112, no. 2, pp. 197–208, 2003. View at Publisher · View at Google Scholar · View at Scopus