Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals

Table 3

Associations between measures of insulin sensitivity and intrahepatic lipid before and after adjusting for NEFA suppression at 30 and 60 minutes.

	Model 1^a			Model 2^b			Model 3^c
	β	95% CI	P	β	95% CI	P	β	95% CI	P
LAR	1.11	[1.01, 1.21]	0.026	1.05	[0.96, 1.16]	0.29	1.06	[0.96, 1.16]	0.24
OGIS	0.99	[0.99, 1.00]	<0.001	0.99	[0.99, 1.00]	<0.001	0.99	[0.99, 0.99]	<0.001
HOMA-IR	1.78	[1.24, 2.55]	0.002	1.69	[1.20, 2.38]	0.003	1.79	[1.28, 2.49]	0.001

Intrahepatic lipid was log transformed in all analyses, and then beta coefficients and confidence intervals were back transformed.
aBeta represents the ratio of geometric mean IHL per 1 unit increase in relevant exposure. Association with intrahepatic lipid is adjusted for age, gender, MR VAT, and alcohol consumption.
^bAs per model 1 with additional adjustment for NEFA suppression at 30 minutes.
^cAs per model 1 with additional adjustment for NEFA suppression at 60 minutes.
HOMA: homeostasis model assessment.
LAR: leptin : adiponectin ratio.
OGIS: oral glucose insulin sensitivity.