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International Journal of Endocrinology
Volume 2013, Article ID 969038, 8 pages
Research Article

Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients

1Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Krakow, Poland
2Chair and Department of Histology, Jagiellonian University Medical College, 31-501 Krakow, Poland
3Department of Medical Diagnostics, Jagiellonian University Medical College, 31-501 Krakow, Poland
4Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Krakow, Poland

Received 10 August 2013; Revised 15 November 2013; Accepted 19 November 2013

Academic Editor: Umberto Campia

Copyright © 2013 Katarzyna Janda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The objective of the study was to assess the relationship between selected clinical and biochemical parameters of end stage renal disease (ESRD) patients and arterial calcification. Materials and Methods. The study comprised 59 stage 5 chronic kidney disease patients (36 hemodialyzed and 23 predialysis). The examined parameters included common carotid artery intima-media thickness (CCA-IMT), BMI, incidence of diabetes and impaired fasting glucose (IFG), dyslipidemia, hypertension, and 3-year mortality. Plasma levels asymmetric dimethylarginine (ADMA), osteopontin (OPN), osteoprotegerin (OPG), and osteocalcin (OC) were also measured. Fragments of radial artery obtained during creation of hemodialysis access were stained for calcifications using von Kossa method and alizarin red. Results. Calcification of radial artery was significantly associated with higher prevalence of IFG and diabetes ( ) and older age ( ), as well as higher OPG ( ) and ADMA concentrations ( ). Fasting glucose  mmol/l (IFG and diabetes) significantly predicted vascular calcification in multiple logistic regression. The calcification was also associated with higher CCA-IMT ( ) and mortality ( ; OR for death 5.39 [1.20–24.1] after adjustment for dialysis status and age). Conclusion. Combination of renal insufficiency and hyperglycemic conditions exerts a synergistic effect on vascular calcification and increases the risk of death.