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International Journal of Endocrinology
Volume 2013, Article ID 970946, 8 pages
Review Article

Growth Retardation in Children with Kidney Disease

1Pediatric Nephrology Unit, Hospital Exequiel Gonzalez Cortes, Ramón Barros Luco 3301, Santiago, Chile
2Faculty of Medicine, University of Chile, Av. Independencia 1027, Santiago, Chile
3Faculty of Medicine, Catholic University, Av Libertador Bernardo O Higgins 340, Santiago, Chile
4Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Casilla 226-3, Santiago, Chile

Received 26 July 2013; Accepted 23 August 2013

Academic Editor: Primus E. Mullis

Copyright © 2013 Paulina Salas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Growth failure is almost inextricably linked with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Growth failure in CKD has been associated with both increased morbidity and mortality. Growth failure in the setting of kidney disease is multifactorial and is related to poor nutritional status as well as comorbidities, such as anemia, bone and mineral disorders, and alterations in hormonal responses, as well as to aspects of treatment such as steroid exposure. This review covers updated management of growth failure in these children including adequate nutrition, treatment of metabolic alterations, and early administration of recombinant human growth hormone (GH).