Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice

Figure 2

Effect of high-fat diet on metabolic parameters in wild-type and MHCII^Δ/Δ mice. Open circle/bars represent wild-type and closed circle/bars MHCII^Δ/Δ mice (wild-type: 𝑛=25, MHCII^Δ/Δ: 𝑛=20). Data are presented as mean ± SEM. (a) Body weight gain during 4-month diet. (b) Glucose tolerance test was performed around the 15th week of the intervention. (c) Liver weight at 16th week. (d) Fasting plasma insulin concentration at 16th week. (e) Fasting blood glucose concentration at 16th week.

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